Maryam Rahman

Maryam Rahman, M.D., M.S.

Associate Professor

Department: MD-NEUROLOGICAL SURGERY
Business Phone: (352) 273-9000

About Maryam Rahman

My name is Maryam Rahman, MD, and I hold the title of associate professor in the department of neurosurgery at the University of Florida College of Medicine. I received my bachelor’s degree in chemistry from Johns Hopkins University before attending medical school and completing a neurosurgical residency at UF. During my training, I completed a two-year, neuro-oncology fellowship under the direction of world-renowned scientist Brent Reynolds, PhD, studying tumor stem cells and their role in developing novel therapies for brain tumors. Following residency, I completed a surgical neuro-oncology fellowship at Johns Hopkins University.

As a brain cancer specialist, I am dedicated to finding a cure for brain tumors. My laboratory focuses on identifying novel immunotherapy approaches to overcome resistance in patients with brain cancer. My current projects include the development of vaccines for the treatment of brain tumors and combining immunotherapy with MRI-guided laser ablation. I am proud to have my work supported by grants from the National Institutes of Health, the Preston A. Wells Jr. endowment and private foundations. Additionally, my translational research is actively being tested in human clinical trials. I have published more than 100 peer-reviewed articles in addition to multiple book chapters and have been invited to speak at various national conferences and events.

I was the first female president of the Florida Neurosurgical Society and served on the executive committee of the Congress of Neurological Surgeons. I also served on the Executive Committee of Women in Neurosurgery.

Teaching Profile

Courses Taught
2018
BMS6020 Clinical Neuroscience
2018
MDT7801 Elect Top/Neuroscienc
2018
MDC7600 Surgery Clerkship
2018
MDT7650 Elect Top/Neurol Surg
2018
MDT7090 Elective Topics
2023-2024
GMS6905 Independent Studies in Medical Sciences
2024
BMS6816 Cancer Bio Clin Oncol

Clinical Profile

Specialties
  • Cancer
Subspecialties
  • Neurosurgery
Areas of Interest
  • Acoustic neuroma
  • Arachnoid cyst
  • Brain Surgery
  • Brain Tumors
  • Glioblastoma multiforme
  • Meningioma

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-3193-1273

Publications

2023
Clinical management of seizures in patients with meningiomas: Efficacy of surgical resection for seizure control and patient-tailored postoperative anti-epileptic drug management.
Neuro-oncology advances. 5(Suppl 1):i58-i66 [DOI] 10.1093/noajnl/vdac136. [PMID] 37287578.
2023
Duration of Prophylactic Levetiracetam After Surgery for Brain Tumor: A Prospective Randomized Trial.
Neurosurgery. 92(1):68-74 [DOI] 10.1227/neu.0000000000002164. [PMID] 36156532.
2023
In Reply to the Letter to the Editor Regarding “Histologic Findings at the Time of Repeat Resection Predicts Survival in Patients with Glioblastoma”.
World neurosurgery. 170 [DOI] 10.1016/j.wneu.2022.12.037. [PMID] 36782416.
2023
mRNA aggregates harness danger response for potent cancer immunotherapy.
medRxiv : the preprint server for health sciences. [DOI] 10.1101/2023.03.12.23287108. [PMID] 36993772.
2023
mRNA challenge predicts brain cancer immunogenicity and response to checkpoint inhibitors.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.03.18.532056. [PMID] 36993158.
2022
Clival Paraganglioma, Case Report and Literature Review.
OBM neurobiology. 6(3) [DOI] 10.21926/obm.neurobiol.2203128. [PMID] 35844205.
2022
Contemporary RNA Therapeutics for Glioblastoma.
Neuromolecular medicine. 24(1):8-12 [DOI] 10.1007/s12017-021-08669-9. [PMID] 34101090.
2022
Glioma Immunotherapy: Advances and Challenges for Spinal Cord Gliomas
Neurospine. 19(1):13-29 [DOI] 10.14245/ns.2143210.605. [PMID] 35130421.
2022
Heterogeneity of glioblastoma stem cells in the context of the immune microenvironment and geospatial organization.
Frontiers in oncology. 12 [DOI] 10.3389/fonc.2022.1022716. [PMID] 36338705.
2022
Histologic Findings at the Time of Repeat Resection Predicts Survival in Patients with Glioblastoma.
World neurosurgery. 168:e451-e459 [DOI] 10.1016/j.wneu.2022.09.128. [PMID] 36206964.
2022
Slow-Cycling Cells in Glioblastoma: A Specific Population in the Cellular Mosaic of Cancer Stem Cells.
Cancers. 14(5) [DOI] 10.3390/cancers14051126. [PMID] 35267434.
2022
Visualization of the perivenous glymphatic efflux in human brain after laser interstitial thermal therapy.
Magnetic resonance imaging. 92:96-99 [DOI] 10.1016/j.mri.2022.06.013. [PMID] 35764218.
2021
A modeling approach to derive baseline risk estimates for GRADE recommendations: Concepts, development, and results of its application to the American Society of Hematology 2019 guidelines on prevention of venous thromboembolism in surgical hospitalized patients.
Journal of clinical epidemiology. 140:69-78 [DOI] 10.1016/j.jclinepi.2021.07.010. [PMID] 34284102.
2021
A review of glioblastoma immunotherapy.
Journal of neuro-oncology. 151(1):41-53 [DOI] 10.1007/s11060-020-03448-1. [PMID] 32253714.
2021
Glioblastoma with a primitive neuroectodermal component: two cases with implications for glioblastoma cell-of-origin.
Clinical imaging. 73:139-145 [DOI] 10.1016/j.clinimag.2020.10.041. [PMID] 33406475.
2020
Adult immuno-oncology: using past failures to inform the future.
Neuro-oncology. 22(9):1249-1261 [DOI] 10.1093/neuonc/noaa116. [PMID] 32391559.
2020
Comparing Standard Performance and Outcome Measures in Hospitalized Pituitary Tumor Patients with Secretory versus Nonsecretory Tumors.
World neurosurgery. 135:e510-e519 [DOI] 10.1016/j.wneu.2019.12.059. [PMID] 31863896.
2020
Epidemiology of Brain Metastases.
Neurosurgery clinics of North America. 31(4):481-488 [DOI] 10.1016/j.nec.2020.06.001. [PMID] 32921345.
2020
Impact of Extent of Resection on Incidence of Postoperative Complications in Patients With Glioblastoma.
Neurosurgery. 86(5):625-630 [DOI] 10.1093/neuros/nyz313. [PMID] 31342060.
2020
Pharmacologic thromboprophylaxis in adult patients undergoing neurosurgical interventions for preventing venous thromboembolism.
Blood advances. 4(12):2798-2809 [DOI] 10.1182/bloodadvances.2020002195. [PMID] 32574367.
2020
Virtual education in neurosurgery during the COVID-19 pandemic
Neurosurgical Focus. 49(6) [DOI] 10.3171/2020.9.FOCUS20672.
2019
American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients.
Blood advances. 3(23):3898-3944 [DOI] 10.1182/bloodadvances.2019000975. [PMID] 31794602.
2019
CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors.
Nature communications. 10(1) [DOI] 10.1038/s41467-019-11869-4. [PMID] 31488817.
2019
Modulation of temozolomide dose differentially affects T-cell response to immune checkpoint inhibition.
Neuro-oncology. 21(6):730-741 [DOI] 10.1093/neuonc/noz015. [PMID] 30668768.
2019
Reimbursement patterns for neurosurgery: Analysis of the NERVES survey results from 2011-2016.
Clinical neurology and neurosurgery. 184 [DOI] 10.1016/j.clineuro.2019.105406. [PMID] 31302381.
2019
The role of CMV in glioblastoma and implications for immunotherapeutic strategies.
Oncoimmunology. 8(1) [DOI] 10.1080/2162402X.2018.1514921. [PMID] 30546954.
2018
Analysis of immunobiologic markers in primary and recurrent glioblastoma
Journal of Neuro-Oncology. 137(2):249-257 [DOI] 10.1007/s11060-017-2732-1. [PMID] 29302887.
2018
Personalized Tumor RNA Loaded Lipid-Nanoparticles Prime the Systemic and Intratumoral Milieu for Response to Cancer Immunotherapy.
Nano letters. 18(10):6195-6206 [DOI] 10.1021/acs.nanolett.8b02179. [PMID] 30259750.
2018
Techniques to Ensure Accurate Targeting for Delivery of Awake Laser Interstitial Thermotherapy.
Operative neurosurgery (Hagerstown, Md.). 15(4):454-460 [DOI] 10.1093/ons/opx290. [PMID] 29444286.
2017
A Contemporary Framework of Language Processing in the Human Brain in the Context of Preoperative and Intraoperative Language Mapping
Neuroradiology. 59(1):69-87 [DOI] 10.1007/s00234-016-1772-0.
2017
Prophylactic Antiepileptic Drug Use in Patients With Brain Tumors Undergoing Craniotomy
World Neurosurgery. 98:28-33 [DOI] 10.1016/j.wneu.2016.10.079.
2017
Reduction of Motion Artifacts and Noise Using Independent Component Analysis in Task-Based Functional MRI for Preoperative Planning in Patients with Brain Tumor
American Journal of Neuroradiology. 38(2):336-342 [DOI] 10.3174/ajnr.a4996.
2017
The Effects of New or Worsened Postoperative Neurological Deficits on Survival of Patients With Glioblastoma
Journal of Neurosurgery. 127(1):123-131 [DOI] 10.3171/2016.7.JNS16396.
2016
Do Tumor and Ventricular Volume Predict the Need for Postresection Shunting in Colloid Cyst Patients?
Journal of Neurosurgery. 125(3):585-590 [DOI] 10.3171/2015.9.JNS151183.
2016
Variant Neurogenic Stunned Myocardium in a Young Female After Subarachnoid Hemorrhage
A&A practice. 6(1):10-13 [DOI] 10.1213/XAA.0000000000000172. [PMID] 26422453.
2015
Effects of Perioperative Acetyl Salicylic Acid on Clinical Outcomes in Patients Undergoing Craniotomy for Brain Tumor.
World neurosurgery. 84(1):41-7 [DOI] 10.1016/j.wneu.2015.02.016. [PMID] 25727304.
2015
Health disparities and stroke: the influence of insurance status on the prevalence of patient safety indicators and hospital-acquired conditions.
Journal of neurosurgery. 122(4):870-5 [DOI] 10.3171/2014.12.JNS14646. [PMID] 25658779.
2015
Insurance status influences the rates of reportable quality metrics in brain tumor patients: a nationwide inpatient sample study.
Neurosurgery. 76(3):239-47; discussion 247 [DOI] 10.1227/NEU.0000000000000594. [PMID] 25603104.
2014
The risk of malignancy anywhere in the body after linear accelerator (LINAC) stereotactic radiosurgery.
Stereotactic and functional neurosurgery. 92(5):323-33 [DOI] 10.1159/000365225. [PMID] 25277349.
2013
Controlling tumor invasion: bevacizumab and BMP4 for glioblastoma.
Future oncology (London, England). 9(9):1389-96 [DOI] 10.2217/fon.13.96. [PMID] 23980685.
2013
Establishing standard performance measures for adult stroke patients: a nationwide inpatient sample database study.
World neurosurgery. 80(6):699-708.e2 [DOI] 10.1016/j.wneu.2013.08.024. [PMID] 23994132.
2013
Prevalence of patient safety indicators and hospital-acquired conditions in those treated for unruptured cerebral aneurysms: establishing standard performance measures using the Nationwide Inpatient Sample database.
Journal of neurosurgery. 119(4):966-73 [DOI] 10.3171/2013.5.JNS122378. [PMID] 23746098.
2013
The prevalence of patient safety indicators and hospital-acquired conditions in patients with ruptured cerebral aneurysms: establishing standard performance measures using the Nationwide Inpatient Sample database.
Journal of neurosurgery. 119(6):1633-40 [DOI] 10.3171/2013.7.JNS13595. [PMID] 23991899.
2012
The future of glioma treatment: stem cells, nanotechnology and personalized medicine.
Future oncology (London, England). 8(9):1149-56 [DOI] 10.2217/fon.12.111. [PMID] 23030489.
2011
Atypical Rasmussen’s encephalitis treated with temporal lobectomy.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 18(2):287-90 [DOI] 10.1016/j.jocn.2010.05.011. [PMID] 21163652.
2011
DBS candidates that fall short on a levodopa challenge test: alternative and important indications.
The neurologist. 17(5):263-8 [DOI] 10.1097/NRL.0b013e31822d1069. [PMID] 21881468.
2011
Ethynyldeoxyuridine (EdU) suppresses in vitro population expansion and in vivo tumor progression of human glioblastoma cells.
Journal of neuro-oncology. 105(3):485-98 [DOI] 10.1007/s11060-011-0621-6. [PMID] 21643840.
2011
Evidence for label-retaining tumour-initiating cells in human glioblastoma.
Brain : a journal of neurology. 134(Pt 5):1331-43 [DOI] 10.1093/brain/awr081. [PMID] 21515906.
2011
Investigational therapies for brain metastases.
Neurosurgery clinics of North America. 22(1):87-96, vii [DOI] 10.1016/j.nec.2010.08.008. [PMID] 21109153.
2011
Midterm Clinical and Angiographic Follow Up for the First Fda-Approved Prospective, Single-Arm Trial of Primary Stenting for Stroke: Saris (Stent-Assisted Recanalization for Acute Ischemic Stroke)
. 42
2011
Midterm clinical and angiographic follow-up for the first Food and Drug Administration-approved prospective, Single-Arm Trial of Primary Stenting for Stroke: SARIS (Stent-Assisted Recanalization for Acute Ischemic Stroke).
Neurosurgery. 69(4):915-20; discussion 920 [DOI] 10.1227/NEU.0b013e318222afd1. [PMID] 21552168.
2011
Purification of immature neuronal cells from neural stem cell progeny.
PloS one. 6(6) [DOI] 10.1371/journal.pone.0020941. [PMID] 21687800.
2011
Recanalization therapy for acute ischemic stroke, part 1: surgical embolectomy and chemical thrombolysis.
Neurosurgical review. 34(1):1-9 [DOI] 10.1007/s10143-010-0293-2. [PMID] 21107631.
2011
Recanalization therapy for acute ischemic stroke, part 2: mechanical intra-arterial technologies.
Neurosurgical review. 34(1):11-20 [DOI] 10.1007/s10143-010-0294-1. [PMID] 21107630.
2011
Spontaneous intracranial hypotension: dilemmas in diagnosis.
Neurosurgery. 69(1):4-14; discussion 14 [DOI] 10.1227/NEU.0b013e3182134399. [PMID] 21368701.
2011
The cancer stem cell hypothesis: failures and pitfalls.
Neurosurgery. 68(2):531-45; discussion 545 [DOI] 10.1227/NEU.0b013e3181ff9eb5. [PMID] 21135745.
2011
Unruptured cerebral aneurysms do not shrink when they rupture: multicenter collaborative aneurysm study group.
Neurosurgery. 68(1):155-60; discussion 160 [DOI] 10.1227/NEU.0b013e3181ff357c. [PMID] 21150760.
2010
Circulating Tumor Cells (Ctcs) in Patients With Glioblastoma Multiforme (Gbm)
Neuro-Oncology. 12
2010
Size ratio correlates with intracranial aneurysm rupture status: a prospective study.
Stroke. 41(5):916-20 [DOI] 10.1161/STROKEAHA.109.574244. [PMID] 20378866.
2009
Anatomic study of the infraorbital foramen for radiofrequency neurotomy of the infraorbital nerve.
Neurosurgery. 64(5 Suppl 2):423-7; discussion 427 [DOI] 10.1227/01.NEU.0000336327.10368.79. [PMID] 19404120.
2009
Early history of the stereotactic apparatus in neurosurgery.
Neurosurgical focus. 27(3) [DOI] 10.3171/2009.7.FOCUS09118. [PMID] 19722814.
2009
Hyponatremia in neurosurgical patients: clinical guidelines development.
Neurosurgery. 65(5):925-35; discussion 935 [DOI] 10.1227/01.NEU.0000358954.62182.B3. [PMID] 19834406.
2009
Stereotactic radiosurgery and the linear accelerator: accelerating electrons in neurosurgery.
Neurosurgical focus. 27(3) [DOI] 10.3171/2009.7.FOCUS09116. [PMID] 19722815.
2008
Comparison of techniques for decompressive lumbar laminectomy: the minimally invasive versus the “classic” open approach.
Minimally invasive neurosurgery : MIN. 51(2):100-5 [DOI] 10.1055/s-2007-1022542. [PMID] 18401823.
1965
Hepatic amoebiasis.
The Journal of the Association of Physicians of India. 13(10):767-74 [PMID] 5840786.

Grants

Jun 2023 ACTIVE
UFR CTSI Instituitonal Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Aug 2022 ACTIVE
A phase I study of RNA-lipid particle vaccines for newly-diagnosed glioblastoma, IND19304 05/21/2020
Role: Co-Investigator
Funding: US FOOD AND DRUG ADMN
Jun 2022 – Aug 2022
Role of Natural Killer Cells in Efficacy of a Novel Glioblastoma mRNA Vaccine
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
Jul 2021 – Jun 2023
Analysis of gene expression profiling in banked blood samples to identify molecular and immune markers of effects of immune activation by LITT plus immune checkpoint inhibitors in glioblastoma by single cell analysis
Role: Principal Investigator
Funding: MONTERIS MEDICAL
Jun 2021 – Aug 2021
The Immune Effects of a Novel Vaccine in Combination with Standard of Care
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
Feb 2021 ACTIVE
Overcoming the blood-brain barrier with nanoparticle vaccines against gliomas
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jul 2020 – Dec 2023
Hydrogel vaccine immunotherapy against brain tumor
Role: Principal Investigator
Funding: UF FOUNDATION
Jul 2020 – Jun 2023
In situ modulation of DC vaccine to improve the immunotherapy efficacy against brain tumor by biocompatible Polyacrylamide-PEG hydrogel
Role: Principal Investigator
Funding: UF FOUNDATION
Dec 2019 – Aug 2021
A vaccine strategy to overcome treatment induced immunosuppression in glioma
Role: Principal Investigator
Funding: AMER BRAIN TUMOR ASSOCIATION
Sep 2019 ACTIVE
Recurrent Brain Metastasis Immune Effects and RespOnse to Laser Interstitial ThermotHerapy (LITT) and Pembrolizumab in Combination (TORCH)
Role: Principal Investigator
Funding: MONTERIS MEDICAL
Jul 2018 ACTIVE
Florida Center for Brain Tumor Research
Role: Principal Investigator
Funding: FL DEPT OF HLTH
Dec 2016 – Nov 2022
Leveraging Temozolomide to Improve Treatment Efficacy of Immune Checkpoint Blockade in Glioblastoma
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jul 2016 – Jun 2018
USING SR233 FOR ENHANCING CELLULAR MIGRATION IN DENDRITICELL VACCINE THERAPY FOR MALIGNANT BRAIN TUMORS
Role: Principal Investigator
Funding: OCALA ROYAL DAMES FOR CANCER RESEARCH
Feb 2015 – Oct 2023
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jul 2013 – Jun 2021
Florida Center for Brain Tumor Research – Statewide Brain Tumor Registry Program at the McKnight Brain Institute
Role: Project Manager
Funding: FL DEPT OF HLTH

Education

Residency – Surgery
2006 · University of Florida
Medical Degree
2005 · University of Florida
Residency – Neurological Surgery
0000 · University of Florida

Contact Details

Phones:
Business:
(352) 273-9000
Addresses:
Business Mailing:
DEPT OF NEUROSURGERY
PO BOX 100265
GAINESVILLE FL 326100265
Business Street:
L2-100
Department of Neurosurgery
1149 Newell Dr.
GAINESVILLE FL 326100001