Steven T DeKosky

Steven T DeKosky, MD

Deputy Director, McKnight Brain Institute; Aerts-Cosper Professor Of Alzheimer's Research; Associate Director 1Florida AD Research Center' And Professor Of Neurology & Neuroscience

Department: MD-BEHAVIORAL NEUROLOGY
Business Phone: (352) 273-8500

About Steven T DeKosky

Dr. DeKosky, a prominent Alzheimer’s disease and traumatic brain injury researcher and UF alumnus, came to UF in July 2015 as the institute’s deputy director and professor of neurology in the College of Medicine. Prior to joining the McKnight Brain Institute, Dr. DeKosky was vice president and dean of the University of Virginia School of Medicine from 2008 to 2013, and was then appointed emeritus professor of neurology . Prior to becoming dean at UVA, he spent 18 years at the University of Pittsburgh in roles that included chair of the department of neurology and director of the Alzheimer’s Disease Research Center. As a researcher, Dr. DeKosky focused on understanding the neurochemistry, neuroimaging, treatment and prevention of Alzheimer’s disease in both his laboratory and in clinical research. He also co-authored the first report of the dementia associated with traumatic brain injuries among professional football players and published extensively in basic research of TBI.. At UF, Dr. DeKosky did graduate work in psychology and neuroscience, received a medical degree in 1974 and following an internship at The Johns Hopkins Hospital, returned to UF to complete a residency in neurology, followed by a fellowship in neurochemistry at the University of Virginia Center for Neurosciences.

Accomplishments

Best Doctors in America
2003-2013 · Best Doctors, Inc.

Teaching Profile

Courses Taught
2019,2021
GMS6757 Introduction to Alzheimer’s Disease and Related Dementias: Clinical and Mechanistic Principles
2018
GMS7980 Research for Doctoral Dissertation

Board Certifications

  • Neurology
    American Board of Psychiatry and Neurology
  • Recertification in Neurology 2015-2025
    American Board of Psychiatry and Neurology

Clinical Profile

Specialties
  • Neurology
Areas of Interest
  • Alzheimer disease
  • Dementia
  • Neurocognitive disorder

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-3743-2758

Publications

2024
Develop and Validate a Computable Phenotype for the Identification of Alzheimer’s Disease Patients Using Electronic Health Record Data.
medRxiv : the preprint server for health sciences. [DOI] 10.1101/2024.02.06.24302389. [PMID] 38370766.
2024
Different aspects of failing to recover from proactive semantic interference predicts rate of progression from amnestic mild cognitive impairment to dementia.
Frontiers in aging neuroscience. 16 [DOI] 10.3389/fnagi.2024.1336008. [PMID] 38357533.
2024
Examining the relationship between anxiety and regional brain volumes in the National Alzheimer’s Coordinating Center uniform, imaging, and biomarker datasets.
Cerebral circulation – cognition and behavior. 6 [DOI] 10.1016/j.cccb.2024.100201. [PMID] 38312309.
2024
Frontal-temporal regional differences in brain energy metabolism and mitochondrial function using 31P MRS in older adults.
GeroScience. [DOI] 10.1007/s11357-023-01046-3. [PMID] 38225480.
2024
Heterogeneous treatment effects of metformin on risk of dementia in patients with type 2 diabetes: A longitudinal observational study.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 20(2):975-985 [DOI] 10.1002/alz.13480. [PMID] 37830443.
2024
Learning ratio performance on a brief visual learning and memory test moderates cognitive training gains in Double Decision task in healthy older adults.
GeroScience. [DOI] 10.1007/s11357-024-01115-1. [PMID] 38457007.
2024
Pain intensity, physical function, and depressive symptoms associated with discontinuing long-term opioid therapy in older adults with Alzheimer’s disease and related dementias.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 20(2):1026-1037 [DOI] 10.1002/alz.13489. [PMID] 37855270.
2024
Plasma Alzheimer’s biomarkers and brain amyloid in Hispanic and non-Hispanic older adults.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 20(1):437-446 [DOI] 10.1002/alz.13456. [PMID] 37671801.
2024
Prevalence and trend of central nervous system-active medication polypharmacy among US commercially insured adults with vs without early-onset dementia: a multi-year cross-sectional study.
Alzheimer's research & therapy. 16(1) [DOI] 10.1186/s13195-024-01405-y. [PMID] 38326897.
2024
tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT).
Brain stimulation. 17(2):283-311 [DOI] 10.1016/j.brs.2024.02.021. [PMID] 38438012.
2024
The impact of a tDCS and cognitive training intervention on task-based functional connectivity.
GeroScience. [DOI] 10.1007/s11357-024-01077-4. [PMID] 38265579.
2023
A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer’s disease using an indwelling CSF catheter.
Translational neurodegeneration. 12(1) [DOI] 10.1186/s40035-023-00358-w. [PMID] 37173791.
2023
Air pollution and dementia in older adults in the Ginkgo Evaluation of Memory Study.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 19(2):549-559 [DOI] 10.1002/alz.12654. [PMID] 35436383.
2023
Assess the documentation of cognitive tests and biomarkers in electronic health records via natural language processing for Alzheimer’s disease and related dementias.
International journal of medical informatics. 170 [DOI] 10.1016/j.ijmedinf.2022.104973. [PMID] 36577203.
2023
Association of longitudinal cognitive decline with diffusion MRI in Gray Matter, Amyloid, and Tau deposition.
Neurobiology of aging. 121:166-178 [DOI] 10.1016/j.neurobiolaging.2022.10.013. [PMID] 36455492.
2023
Biomedical discovery through the integrative biomedical knowledge hub (iBKH).
iScience. 26(4) [DOI] 10.1016/j.isci.2023.106460. [PMID] 37020958.
2023
Connecting memory and functional brain networks in older adults: a resting-state fMRI study.
GeroScience. 45(5):3079-3093 [DOI] 10.1007/s11357-023-00967-3. [PMID] 37814198.
2023
Early prediction of Alzheimer’s disease and related dementias using real-world electronic health records.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 19(8):3506-3518 [DOI] 10.1002/alz.12967. [PMID] 36815661.
2023
Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer’s disease risk
Molecular Psychiatry. 28(10):4451-4462 [DOI] 10.1038/s41380-023-02170-4. [PMID] 37666928.
2023
Identification of Outcome-Oriented Progression Subtypes from Mild Cognitive Impairment to Alzheimer’s Disease Using Electronic Health Records.
AMIA … Annual Symposium proceedings. AMIA Symposium. 2023:764-773 [PMID] 38222396.
2023
Identification of Outcome-Oriented Progression Subtypes from Mild Cognitive Impairment to Alzheimer’s Disease Using Electronic Health Records.
medRxiv : the preprint server for health sciences. [DOI] 10.1101/2023.07.27.23293270. [PMID] 37577594.
2023
Imaging features of small vessel disease in cerebral amyloid angiopathy among patients with Alzheimer’s disease.
NeuroImage. Clinical. 38 [DOI] 10.1016/j.nicl.2023.103437. [PMID] 37245492.
2023
Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease.
Neurobiology of aging. 122:107-111 [DOI] 10.1016/j.neurobiolaging.2022.11.007. [PMID] 36528961.
2023
Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease.
Acta neuropathologica communications. 11(1) [DOI] 10.1186/s40478-023-01563-4. [PMID] 37101235.
2023
Mediation of Reduced Hippocampal Volume by Cerebral Amyloid Angiopathy in Pathologically Confirmed Patients with Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD. 93(2):495-507 [DOI] 10.3233/JAD-220624. [PMID] 37038809.
2023
Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 19(11):5010-5022 [DOI] 10.1002/alz.13064. [PMID] 37089073.
2023
Newer glucose-lowering drugs and risk of dementia: A systematic review and meta-analysis of observational studies.
Journal of the American Geriatrics Society. 71(7):2096-2106 [DOI] 10.1111/jgs.18306. [PMID] 36821780.
2023
Optical Neuroimaging in Delirium
Photonics. 10(12) [DOI] 10.3390/photonics10121334.
2023
Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial.
Brain stimulation. 16(3):904-917 [DOI] 10.1016/j.brs.2023.05.021. [PMID] 37245842.
2023
Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive.
Frontiers in neurology. 14 [DOI] 10.3389/fneur.2023.1179205. [PMID] 37602238.
2023
Stability in cognitive classification as a function of severity of impairment and ethnicity: A longitudinal analysis.
Applied neuropsychology. Adult. 1-14 [DOI] 10.1080/23279095.2023.2222861. [PMID] 37395391.
2023
Task-based functional connectivity of the Useful Field of View (UFOV) fMRI task.
GeroScience. 45(1):293-309 [DOI] 10.1007/s11357-022-00632-1. [PMID] 35948860.
2023
The Effects of Transcutaneous Vagus Nerve Stimulation on Functional Connectivity Within Semantic and Hippocampal Networks in Mild Cognitive Impairment.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 20(2):419-430 [DOI] 10.1007/s13311-022-01318-4. [PMID] 36477709.
2022
A study of the longitudinal changes in multiple cerebrospinal fluid and volumetric magnetic resonance imaging biomarkers on converter and non-converter Alzheimer’s disease subjects with consideration for their amyloid beta status.
Alzheimer's & dementia (Amsterdam, Netherlands). 14(1) [DOI] 10.1002/dad2.12258. [PMID] 35229014.
2022
A Tensorized Multitask Deep Learning Network for Progression Prediction of Alzheimer’s Disease.
Frontiers in aging neuroscience. 14 [DOI] 10.3389/fnagi.2022.810873. [PMID] 35601611.
2022
A transfer learning approach based on gradient boosting machine for diagnosis of Alzheimer’s disease.
Frontiers in aging neuroscience. 14 [DOI] 10.3389/fnagi.2022.966883. [PMID] 36275004.
2022
Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review of the literature.
Acta neuropathologica communications. 10(1) [DOI] 10.1186/s40478-022-01311-0. [PMID] 35101132.
2022
Association of Cognitive Impairment With Free Water in the Nucleus Basalis of Meynert and Locus Coeruleus to Transentorhinal Cortex Tract.
Neurology. 98(7):e700-e710 [DOI] 10.1212/WNL.0000000000013206. [PMID] 34906980.
2022
Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults.
GeroScience. 44(2):847-866 [DOI] 10.1007/s11357-021-00503-1. [PMID] 34950997.
2022
Cognitive impairment and World Trade Centre-related exposures
Nature Reviews Neurology. 18(2):103-116 [DOI] 10.1038/s41582-021-00576-8. [PMID] 34795448.
2022
Correlations between sleep disturbance and brain structures associated with neurodegeneration in the National Alzheimer’s Coordinating Center Uniform Data Set.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 106:204-212 [DOI] 10.1016/j.jocn.2022.07.012. [PMID] 35970678.
2022
Functional Neural Correlates of a Useful Field of View (UFOV)-Based fMRI Task in Older Adults.
Cerebral cortex (New York, N.Y. : 1991). 32(9):1993-2012 [DOI] 10.1093/cercor/bhab332. [PMID] 34541604.
2022
Genome-Wide Association Study of Incident Dementia in a Community-Based Sample of Older Subjects.
Journal of Alzheimer's disease : JAD. 88(2):787-798 [DOI] 10.3233/JAD-220293. [PMID] 35694926.
2022
Higher white matter hyperintensity load adversely affects pre-post proximal cognitive training performance in healthy older adults.
GeroScience. 44(3):1441-1455 [DOI] 10.1007/s11357-022-00538-y. [PMID] 35278154.
2022
Higher-order resting state network association with the useful field of view task in older adults.
GeroScience. 44(1):131-145 [DOI] 10.1007/s11357-021-00441-y. [PMID] 34431043.
2022
Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults.
GeroScience. 44(2):1011-1027 [DOI] 10.1007/s11357-022-00535-1. [PMID] 35258771.
2022
Risk of Dementia Differs Across Lifestyle Engagement Subgroups: A Latent Class and Time-to-Event Analysis in Community-Dwelling Older Adults.
The journals of gerontology. Series B, Psychological sciences and social sciences. 77(5):872-884 [DOI] 10.1093/geronb/gbab152. [PMID] 34387336.
2022
The association between head motion during functional magnetic resonance imaging and executive functioning in older adults
Neuroimage: Reports. 2(2) [DOI] 10.1016/j.ynirp.2022.100085. [PMID] 37377763.
2022
The Broad Range of Research in Alzheimer’s Disease and Related Dementias
Neurotherapeutics. 19(1):1-7 [DOI] 10.1007/s13311-022-01245-4. [PMID] 35562636.
2022
The longitudinal impact of the COVID-19 pandemic on health behaviors, psychosocial factors, and cognitive functioning in older adults.
Frontiers in aging neuroscience. 14 [DOI] 10.3389/fnagi.2022.999107. [PMID] 36506467.
2021
A Workshop on Cognitive Aging and Impairment in the 9/11-Exposed Population.
International journal of environmental research and public health. 18(2) [DOI] 10.3390/ijerph18020681. [PMID] 33466931.
2021
Agreement of Minimum Data Set 3.0 depression and behavioral symptoms with clinical diagnosis in a nursing home.
Aging & mental health. 25(10):1897-1902 [DOI] 10.1080/13607863.2020.1758921. [PMID] 32447973.
2021
Baseline Neuroimaging Predicts Decline to Dementia From Amnestic Mild Cognitive Impairment.
Frontiers in aging neuroscience. 13 [DOI] 10.3389/fnagi.2021.758298. [PMID] 34950021.
2021
Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients.
Journal of neurotrauma. 38(1):1-43 [DOI] 10.1089/neu.2020.7332. [PMID] 33115334.
2021
Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure.
Molecular psychiatry. 26(10):5940-5954 [DOI] 10.1038/s41380-020-0674-z. [PMID] 32094584.
2021
Case-cohort study of plasma phospholipid fatty acid profiles, cognitive function, and risk of dementia: a secondary analysis in the Ginkgo Evaluation of Memory Study.
The American journal of clinical nutrition. 114(1):154-162 [DOI] 10.1093/ajcn/nqab087. [PMID] 33880495.
2021
Diagnostic criteria for apathy in neurocognitive disorders.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 17(12):1892-1904 [DOI] 10.1002/alz.12358. [PMID] 33949763.
2021
Frontal White Matter Hyperintensities and Executive Functioning Performance in Older Adults.
Frontiers in aging neuroscience. 13 [DOI] 10.3389/fnagi.2021.672535. [PMID] 34262445.
2021
Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults.
Cerebral cortex (New York, N.Y. : 1991). 31(3):1732-1743 [DOI] 10.1093/cercor/bhaa322. [PMID] 33188384.
2021
PET Imaging of Tau Pathology and Amyloid-β, and MRI for Alzheimer’s Disease Feature Fusion and Multimodal Classification.
Journal of Alzheimer's disease : JAD. 84(4):1497-1514 [DOI] 10.3233/JAD-210064. [PMID] 34719488.
2021
Plasma antioxidants and risk of dementia in older adults.
Alzheimer's & dementia (New York, N. Y.). 7(1) [DOI] 10.1002/trc2.12208. [PMID] 34504943.
2021
Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer’s disease modification.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 17(8):1365-1382 [DOI] 10.1002/alz.12302. [PMID] 33559354.
2021
Quality of opioid prescribing in older adults with or without Alzheimer disease and related dementia.
Alzheimer's research & therapy. 13(1) [DOI] 10.1186/s13195-021-00818-3. [PMID] 33883028.
2021
Uncontrolled Pain and Risk for Depression and Behavioral Symptoms in Residents With Dementia.
Journal of the American Medical Directors Association. 22(10):2079-2086.e5 [DOI] 10.1016/j.jamda.2021.05.010. [PMID] 34089652.
2021
Utility of Plasma Neurofilament Light in the 1Florida Alzheimer’s Disease Research Center (ADRC).
Journal of Alzheimer's disease : JAD. 79(1):59-70 [DOI] 10.3233/JAD-200901. [PMID] 33216030.
2020
A novel method of evaluating semantic intrusion errors to distinguish between amyloid positive and negative groups on the Alzheimer’s disease continuum.
Journal of psychiatric research. 124:131-136 [DOI] 10.1016/j.jpsychires.2020.02.008. [PMID] 32146222.
2020
Acute Effects of Sport-Related Concussion on Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase L1, Total Tau, and Neurofilament Light Measured by a Multiplex Assay.
Journal of neurotrauma. 37(13):1537-1545 [DOI] 10.1089/neu.2019.6831. [PMID] 32024456.
2020
Alcohol Consumption, Brain Amyloid-β Deposition, and Brain Structural Integrity Among Older Adults Free of Dementia.
Journal of Alzheimer's disease : JAD. 74(2):509-519 [DOI] 10.3233/JAD-190834. [PMID] 32039843.
2020
Association of Apolipoprotein E in Lipoprotein Subspecies With Risk of Dementia.
JAMA network open. 3(7) [DOI] 10.1001/jamanetworkopen.2020.9250. [PMID] 32648923.
2020
Brain health INnovation Diplomacy: a model binding diverse disciplines to manage the promise and perils of technological innovation.
International psychogeriatrics. 32(8):955-979 [DOI] 10.1017/S1041610219002266. [PMID] 32019621.
2020
Comorbid Pain and Cognitive Impairment in a Nationally Representative Adult Population: Prevalence and Associations With Health Status, Health Care Utilization, and Satisfaction With Care.
The Clinical journal of pain. 36(10):725-739 [DOI] 10.1097/AJP.0000000000000863. [PMID] 32740305.
2020
Contributions of Hippocampal Volume to Cognition in Healthy Older Adults.
Frontiers in aging neuroscience. 12 [DOI] 10.3389/fnagi.2020.593833. [PMID] 33250765.
2020
Dual sensory impairment in older adults and risk of dementia from the GEM Study.
Alzheimer's & dementia (Amsterdam, Netherlands). 12(1) [DOI] 10.1002/dad2.12054. [PMID] 32671180.
2020
High density lipoprotein and its apolipoprotein-defined subspecies and risk of dementia.
Journal of lipid research. 61(3):445-454 [DOI] 10.1194/jlr.P119000473. [PMID] 31892526.
2020
Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.
Neurology. 94(3):e267-e281 [DOI] 10.1212/WNL.0000000000008732. [PMID] 31827004.
2020
Predicting resistance to amyloid-beta deposition and cognitive resilience in the oldest-old.
Neurology. 95(8):e984-e994 [DOI] 10.1212/WNL.0000000000010239. [PMID] 32699143.
2020
Structural Neural Correlates of Double Decision Performance in Older Adults.
Frontiers in aging neuroscience. 12 [DOI] 10.3389/fnagi.2020.00278. [PMID] 33117145.
2020
The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease.
Alzheimer's research & therapy. 12(1) [DOI] 10.1186/s13195-020-00588-4. [PMID] 32122400.
2020
The Long and the Short of Benzodiazepines and Sleep Medications: Short-Term Benefits, Long-Term Harms?
Neurotherapeutics. 17(1):153-155 [DOI] 10.1007/s13311-019-00827-z. [PMID] 31907875.
2020
The Role of Resting-State Network Functional Connectivity in Cognitive Aging.
Frontiers in aging neuroscience. 12 [DOI] 10.3389/fnagi.2020.00177. [PMID] 32595490.
2020
Time-to-change: dementia care in COVID-19.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. 20(5):792-793 [DOI] 10.1111/psyg.12576. [PMID] 32510762.
2020
West Nile Virus-Induced Neurologic Sequelae-Relationship to Neurodegenerative Cascades and Dementias.
Current tropical medicine reports. 7(1):25-36 [DOI] 10.1007/s40475-020-00200-7. [PMID] 32775145.
2019
A cognitive stress test for prodromal Alzheimer’s disease: Multiethnic generalizability.
Alzheimer's & dementia (Amsterdam, Netherlands). 11:550-559 [DOI] 10.1016/j.dadm.2019.05.003. [PMID] 31417955.
2019
A phase 1 clinical trial of the sigma-2 receptor complex allosteric antagonist CT1812, a novel therapeutic candidate for Alzheimer’s disease.
Alzheimer's & dementia (New York, N. Y.). 5:20-26 [DOI] 10.1016/j.trci.2018.11.001. [PMID] 30723776.
2019
Acute and chronic effects of single dose memantine after controlled cortical impact injury in adult rats.
Restorative neurology and neuroscience. 37(3):245-263 [DOI] 10.3233/RNN-190909. [PMID] 31177251.
2019
Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults With or Without Mild Cognitive Impairment.
JAMA network open. 2(9) [DOI] 10.1001/jamanetworkopen.2019.10319. [PMID] 31560382.
2019
Blood amyloid levels and risk of dementia in the Ginkgo Evaluation of Memory Study (GEMS): A longitudinal analysis.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 15(8):1029-1038 [DOI] 10.1016/j.jalz.2019.04.008. [PMID] 31255494.
2019
Cause of Death and End-of-Life Experiences in Individuals with Dementia with Lewy Bodies.
Journal of the American Geriatrics Society. 67(1):67-73 [DOI] 10.1111/jgs.15608. [PMID] 30291740.
2019
Community perceptions related to brain donation: Evidence for intervention.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 15(2):267-272 [DOI] 10.1016/j.jalz.2018.09.005. [PMID] 30365929.
2019
Development of a transcallosal tractography template and its application to dementia.
NeuroImage. 200:302-312 [DOI] 10.1016/j.neuroimage.2019.06.065. [PMID] 31260838.
2019
Exploratory study of sport-related concussion effects on peripheral micro-RNA expression.
Brain injury. 33(4):1-7 [DOI] 10.1080/02699052.2019.1573379. [PMID] 30704304.
2019
Free-water imaging of the hippocampus is a sensitive marker of Alzheimer’s disease.
NeuroImage. Clinical. 24 [DOI] 10.1016/j.nicl.2019.101985. [PMID] 31470214.
2019
Pain Assessments in MDS 3.0: Agreement with Vital Sign Pain Records of Nursing Home Residents.
Journal of the American Geriatrics Society. 67(11):2421-2422 [DOI] 10.1111/jgs.16122. [PMID] 31403708.
2019
Preface.
Handbook of clinical neurology. 167 [DOI] 10.1016/B978-0-12-804766-8.09984-2. [PMID] 31753160.
2019
The evolution of geriatric neurology.
Handbook of clinical neurology. 167:575-584 [DOI] 10.1016/B978-0-12-804766-8.00032-7. [PMID] 31753157.
2018
Alzheimer’s disease: The right drug, the right time.
Science (New York, N.Y.). 362(6420):1250-1251 [DOI] 10.1126/science.aau0437. [PMID] 30545877.
2018
Amyloid deposition and brain structure as long-term predictors of MCI, dementia, and mortality.
Neurology. 90(21):e1920-e1928 [DOI] 10.1212/WNL.0000000000005549. [PMID] 29695596.
2018
Amyloid β Deposition and Suspected Non-Alzheimer Pathophysiology and Cognitive Decline Patterns for 12 Years in Oldest Old Participants Without Dementia.
JAMA neurology. 75(1):88-96 [DOI] 10.1001/jamaneurol.2017.3029. [PMID] 29114732.
2018
Apolipoproteins and Alzheimer’s pathophysiology.
Alzheimer's & dementia (Amsterdam, Netherlands). 10:545-553 [DOI] 10.1016/j.dadm.2018.07.001. [PMID] 30370330.
2018
Concussion BASICS II: Baseline serum biomarkers, head impact exposure, and clinical measures.
Neurology. 91(23):e2123-e2132 [DOI] 10.1212/WNL.0000000000006616. [PMID] 30404782.
2018
Concussion BASICS III: Serum biomarker changes following sport-related concussion.
Neurology. 91(23):e2133-e2143 [DOI] 10.1212/WNL.0000000000006617. [PMID] 30404786.
2018
Concussion Biomarkers Assessed in Collegiate Student-Athletes (BASICS) I: Normative study.
Neurology. 91(23):e2109-e2122 [DOI] 10.1212/WNL.0000000000006613. [PMID] 30404785.
2018
Diffusion tensor imaging (DTI) findings in adult civilian, military, and sport-related mild traumatic brain injury (mTBI): a systematic critical review.
Brain imaging and behavior. 12(2):585-612 [DOI] 10.1007/s11682-017-9708-9. [PMID] 28337734.
2018
Glymphatic system disruption as a mediator of brain trauma and chronic traumatic encephalopathy.
Neuroscience and biobehavioral reviews. 84:316-324 [DOI] 10.1016/j.neubiorev.2017.08.016. [PMID] 28859995.
2018
Impact of Amyloid PET Imaging in the Memory Clinic: A Systematic Review and Meta-Analysis.
Journal of Alzheimer's disease : JAD. 64(1):323-335 [DOI] 10.3233/JAD-180239. [PMID] 29889075.
2018
Long-term Mortality in NFL Professional Football Players: No Significant Increase, but Questions Remain.
JAMA. 319(8):773-775 [DOI] 10.1001/jama.2017.20885. [PMID] 29392297.
2018
Military-related risk factors for dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 14(12):1651-1662 [DOI] 10.1016/j.jalz.2018.08.011. [PMID] 30415806.
2018
Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.
British journal of anaesthesia. 121(5):1005-1012 [DOI] 10.1016/j.bja.2017.11.087. [PMID] 30336844.
2018
Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.
Canadian journal of anaesthesia = Journal canadien d'anesthesie. 65(11):1248-1257 [DOI] 10.1007/s12630-018-1216-x. [PMID] 30324338.
2018
Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.
Acta anaesthesiologica Scandinavica. 62(10):1473-1480 [DOI] 10.1111/aas.13250. [PMID] 30325016.
2018
Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and Surgery-2018.
Anesthesia and analgesia. 127(5):1189-1195 [DOI] 10.1213/ANE.0000000000003634. [PMID] 30325748.
2018
Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery-2018.
Anesthesiology. 129(5):872-879 [DOI] 10.1097/ALN.0000000000002334. [PMID] 30325806.
2018
Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery-20181.
Journal of Alzheimer's disease : JAD. 66(1):1-10 [DOI] 10.3233/JAD-189004. [PMID] 30347621.
2018
Semantic Intrusions and Failure to Recover From Semantic Interference in Mild Cognitive Impairment: Relationship to Amyloid and Cortical Thickness.
Current Alzheimer research. 15(9):848-855 [DOI] 10.2174/1567205015666180427122746. [PMID] 29701153.
2018
Utility of Amyloid PET Scans in the Evaluation of Patients Presenting with Diverse Cognitive Complaints.
Journal of Alzheimer's disease : JAD. 66(4):1599-1608 [DOI] 10.3233/JAD-180683. [PMID] 30475766.
2018
Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment.
Neurology. 91(10):e976-e984 [DOI] 10.1212/WNL.0000000000006128. [PMID] 30076274.
2017
Antemortem biomarker support for a diagnosis of clinically probable chronic traumatic encephalopathy.
Molecular psychiatry. 22(5):638-639 [DOI] 10.1038/mp.2016.236. [PMID] 28070125.
2017
Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype.
JAMA neurology. 74(1):82-90 [DOI] 10.1001/jamaneurol.2016.3474. [PMID] 27842173.
2017
Diabetes and Cognitive Decline in Older Adults: The Ginkgo Evaluation of Memory Study.
The journals of gerontology. Series A, Biological sciences and medical sciences. 73(1):123-130 [DOI] 10.1093/gerona/glx076. [PMID] 28510619.
2017
Inflammatory Biomarkers Predict Domain-Specific Cognitive Decline in Older Adults.
The journals of gerontology. Series A, Biological sciences and medical sciences. 72(6):796-803 [DOI] 10.1093/gerona/glw155. [PMID] 27522059.
2017
Injury cascades in TBI-related neurodegeneration.
Brain injury. 31(9):1177-1182 [DOI] 10.1080/02699052.2017.1312528. [PMID] 28981345.
2017
Preventing Dementia: Many Issues and Not Enough Time.
JAMA neurology. 74(5):508-510 [DOI] 10.1001/jamaneurol.2017.0045. [PMID] 28319236.
2017
Recovery from Proactive Semantic Interference and MRI Volume: A Replication and Extension Study.
Journal of Alzheimer's disease : JAD. 59(1):131-139 [DOI] 10.3233/JAD-170276. [PMID] 28598850.
2017
Research Gaps and Controversies in Chronic Traumatic Encephalopathy: A Review.
JAMA neurology. 74(10):1255-1262 [DOI] 10.1001/jamaneurol.2017.2396. [PMID] 28975240.
2016
Cerebral [18 F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy.
Translational psychiatry. 6(9) [DOI] 10.1038/tp.2016.175. [PMID] 27676441.
2016
Cerebrospinal Biomarkers in Alzheimer Disease-Potential Roles as Markers of Prognosis and Neuroplasticity.
JAMA neurology. 73(5):508-10 [DOI] 10.1001/jamaneurol.2016.0090. [PMID] 27019279.
2016
Factors Influencing Clinical Correlates of Chronic Traumatic Encephalopathy (CTE): a Review.
Neuropsychology review. 26(4):340-363 [PMID] 27561662.
2016
Registries and Cohorts to Accelerate Early Phase Alzheimer’s Trials. A Report from the E.U./U.S. Clinical Trials in Alzheimer’s Disease Task Force.
The journal of prevention of Alzheimer's disease. 3(2):68-74 [DOI] 10.14283/jpad.2016.97. [PMID] 29210442.
2016
The Human Alzheimer Disease Project: Answering the Call.
JAMA neurology. 73(4):373-4 [DOI] 10.1001/jamaneurol.2015.4512. [PMID] 26831746.
2016
Valsartan/Sacubitril for Heart Failure: Reconciling Disparities Between Preclinical and Clinical Investigations.
JAMA. 315(1):25-6 [DOI] 10.1001/jama.2015.17632. [PMID] 26641736.
2015
Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer’s disease.
Neurobiology of aging. 36(1):12-9 [DOI] 10.1016/j.neurobiolaging.2014.06.021. [PMID] 25048160.
2015
Expert consensus document: Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions.
Nature reviews. Neurology. 11(4):230-44 [DOI] 10.1038/nrneurol.2015.30. [PMID] 25776822.
2015
Genetic determinants of disease progression in Alzheimer’s disease.
Journal of Alzheimer's disease : JAD. 43(2):649-55 [DOI] 10.3233/JAD-140729. [PMID] 25114068.
2015
Genetic Determinants of Survival in Patientswith Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD. 45(2):651-8 [PMID] 25649651.
2015
Hippocampal plasticity during the progression of Alzheimer’s disease.
Neuroscience. 309:51-67 [DOI] 10.1016/j.neuroscience.2015.03.006. [PMID] 25772787.
2015
Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
JAMA neurology. 72(2):209-16 [DOI] 10.1001/jamaneurol.2014.2157. [PMID] 25531812.
2014
2014 Report on the Milestones for the US National Plan to Address Alzheimer’s Disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 10(5 Suppl):S430-52 [DOI] 10.1016/j.jalz.2014.08.103. [PMID] 25341459.
2014
[18F]-T807 tauopathy PET imaging in chronic traumatic encephalopathy.
F1000Research. 3 [DOI] 10.12688/f1000research.5372.1. [PMID] 25469232.
2014
Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria.
The Lancet. Neurology. 13(6):614-29 [DOI] 10.1016/S1474-4422(14)70090-0. [PMID] 24849862.
2014
Alzheimer disease risk factors–reply.
JAMA neurology. 71(8):1051-2 [DOI] 10.1001/jamaneurol.2014.636. [PMID] 25111207.
2014
Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.
Neurology. 83(20):1804-11 [DOI] 10.1212/WNL.0000000000000977. [PMID] 25305156.
2014
Arterial stiffness and β-amyloid progression in nondemented elderly adults.
JAMA neurology. 71(5):562-8 [DOI] 10.1001/jamaneurol.2014.186. [PMID] 24687165.
2014
Chronic traumatic encephalopathy: clinical-biomarker correlations and current concepts in pathogenesis.
Molecular neurodegeneration. 9 [DOI] 10.1186/1750-1326-9-37. [PMID] 25231386.
2014
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
JAMA neurology. 71(11):1394-404 [DOI] 10.1001/jamaneurol.2014.1491. [PMID] 25199842.
2014
Environmental exposures and the risk for Alzheimer disease: can we identify the smoking guns?
JAMA neurology. 71(3):273-5 [DOI] 10.1001/jamaneurol.2013.6031. [PMID] 24473699.
2014
Infection hospitalization increases risk of dementia in the elderly.
Critical care medicine. 42(5):1037-46 [DOI] 10.1097/CCM.0000000000000123. [PMID] 24368344.
2014
Markers of cholesterol transport are associated with amyloid deposition in the brain.
Neurobiology of aging. 35(4):802-7 [DOI] 10.1016/j.neurobiolaging.2013.09.040. [PMID] 24199960.
2014
Studying the brain: Complexities at every level.
Neurology. 83(12):1040-1 [DOI] 10.1212/WNL.0000000000000800. [PMID] 25128178.
2014
Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury.
Translational psychiatry. 4(9) [DOI] 10.1038/tp.2014.91. [PMID] 25226550.
2014
The role of big data in understanding late-life cognitive decline: E Unum, Pluribus.
JAMA neurology. 71(12):1476-8 [DOI] 10.1001/jamaneurol.2014.2818. [PMID] 25347052.
2013
2012: the year in dementia.
The Lancet. Neurology. 12(1):4-6 [DOI] 10.1016/S1474-4422(12)70284-3. [PMID] 23237888.
2013
Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers.
Nature reviews. Neurology. 9(4):192-200 [DOI] 10.1038/nrneurol.2013.36. [PMID] 23558985.
2013
Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study.
Neurology. 81(10):896-903 [DOI] 10.1212/WNL.0b013e3182a35228. [PMID] 23911756.
2013
Association between performance on Neurology In-Training and Certification Examinations.
Neurology. 80(2):206-9 [DOI] 10.1212/WNL.0b013e31827b92a3. [PMID] 23296130.
2013
Cerebral blood flow changes after brain injury in human amyloid-beta knock-in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 33(6):826-33 [DOI] 10.1038/jcbfm.2013.24. [PMID] 23443172.
2013
Classification of amyloid-positivity in controls: comparison of visual read and quantitative approaches.
NeuroImage. 71:207-15 [DOI] 10.1016/j.neuroimage.2013.01.015. [PMID] 23353602.
2013
Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia.
Neurology. 80(15):1378-84 [DOI] 10.1212/WNL.0b013e31828c2fc8. [PMID] 23516317.
2013
CR1 and the “vanishing amyloid” hypothesis of Alzheimer’s disease.
Biological psychiatry. 73(5):393-5 [DOI] 10.1016/j.biopsych.2013.01.013. [PMID] 23399469.
2013
In vivo assessment of amyloid-β deposition in nondemented very elderly subjects.
Annals of neurology. 73(6):751-61 [DOI] 10.1002/ana.23797. [PMID] 23596051.
2013
Phenotypic variability in three families with valosin-containing protein mutation.
European journal of neurology. 20(2):251-8 [DOI] 10.1111/j.1468-1331.2012.03831.x. [PMID] 22900631.
2013
Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.
Neurology. 81(19):1711-8 [DOI] 10.1212/01.wnl.0000435301.64776.37. [PMID] 24132374.
2013
The long-term effects of conventional and atypical antipsychotics in patients with probable Alzheimer’s disease.
The American journal of psychiatry. 170(9):1051-8 [DOI] 10.1176/appi.ajp.2013.12081046. [PMID] 23896958.
2013
Toward the treatment and prevention of Alzheimer’s disease: rational strategies and recent progress.
Annual review of medicine. 64:367-83 [DOI] 10.1146/annurev-med-092611-084441. [PMID] 23327526.
2012
Acute blast injury reduces brain abeta in two rodent species.
Frontiers in neurology. 3 [DOI] 10.3389/fneur.2012.00177. [PMID] 23267342.
2012
Amyloid imaging in dementias with atypical presentation.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 8(5):389-98 [DOI] 10.1016/j.jalz.2011.07.003. [PMID] 22285638.
2012
Anticipatory grief in new family caregivers of persons with mild cognitive impairment and dementia.
Alzheimer disease and associated disorders. 26(2):159-65 [DOI] 10.1097/WAD.0b013e31822f9051. [PMID] 21946013.
2012
APOE ε4 status and traumatic brain injury on the gridiron or the battlefield.
Science translational medicine. 4(134) [DOI] 10.1126/scitranslmed.3004274. [PMID] 22593171.
2012
Association of CLU and PICALM variants with Alzheimer’s disease.
Neurobiology of aging. 33(3):518-21 [DOI] 10.1016/j.neurobiolaging.2010.04.015. [PMID] 20570404.
2012
Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory Study.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 8(3):188-95 [DOI] 10.1016/j.jalz.2011.03.010. [PMID] 22465175.
2012
Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study.
Acta neuropathologica. 123(3):433-47 [DOI] 10.1007/s00401-012-0943-2. [PMID] 22271153.
2012
Genome-wide association analysis of age-at-onset in Alzheimer’s disease.
Molecular psychiatry. 17(12):1340-6 [DOI] 10.1038/mp.2011.135. [PMID] 22005931.
2012
Genome-wide association study of Alzheimer’s disease with psychotic symptoms.
Molecular psychiatry. 17(12):1316-27 [DOI] 10.1038/mp.2011.125. [PMID] 22005930.
2012
Genome-wide association study of Alzheimer’s disease.
Translational psychiatry. 2(5) [DOI] 10.1038/tp.2012.45. [PMID] 22832961.
2012
Gray matter atrophy associated with extrapyramidal signs in the Lewy body variant of Alzheimer’s disease.
Journal of Alzheimer's disease : JAD. 32(4):1043-9 [DOI] 10.3233/JAD-2012-121108. [PMID] 22886020.
2012
Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study.
Neurology. 79(15):1599-606 [DOI] 10.1212/WNL.0b013e31826e25f0. [PMID] 23019262.
2012
Mild cognitive impairment: pathology and mechanisms.
Acta neuropathologica. 123(1):13-30 [DOI] 10.1007/s00401-011-0884-1. [PMID] 22101321.
2012
Novel late-onset Alzheimer disease loci variants associate with brain gene expression.
Neurology. 79(3):221-8 [DOI] 10.1212/WNL.0b013e3182605801. [PMID] 22722634.
2012
Statins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory study.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 21(6):436-44 [DOI] 10.1016/j.jstrokecerebrovasdis.2010.11.002. [PMID] 21236699.
2011
A medial temporal lobe division of labor: insights from memory in aging and early Alzheimer disease.
Hippocampus. 21(5):461-6 [DOI] 10.1002/hipo.20779. [PMID] 20232383.
2011
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer’s disease.
Nature genetics. 43(5):436-41 [DOI] 10.1038/ng.801. [PMID] 21460841.
2011
Incidence and predictors of advance care planning among persons with cognitive impairment.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 19(8):712-20 [DOI] 10.1097/JGP.0b013e3181faebef. [PMID] 21785291.
2011
Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy.
Archives of general psychiatry. 68(1):51-60 [DOI] 10.1001/archgenpsychiatry.2010.184. [PMID] 21199965.
2011
Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease.
Neurology. 77(1):39-47 [DOI] 10.1212/WNL.0b013e3182231419. [PMID] 21700583.
2011
Replication study of genome-wide associated SNPs with late-onset Alzheimer’s disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 156B(4):507-12 [DOI] 10.1002/ajmg.b.31194. [PMID] 21480501.
2011
Revision of the criteria for Alzheimer’s disease: A symposium.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 7(1):e1-12 [PMID] 21322828.
2011
Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errors.
Archives of neurology. 68(3):329-37 [DOI] 10.1001/archneurol.2010.295. [PMID] 21059987.
2011
The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 7(3):270-9 [DOI] 10.1016/j.jalz.2011.03.008. [PMID] 21514249.
2011
The world of dementia beyond 2020.
Journal of the American Geriatrics Society. 59(5):923-7 [DOI] 10.1111/j.1532-5415.2011.03365.x. [PMID] 21488846.
2010
Chronic traumatic encephalopathy (CTE) in a National Football League Player: Case report and emerging medicolegal practice questions.
Journal of forensic nursing. 6(1):40-6 [DOI] 10.1111/j.1939-3938.2009.01064.x. [PMID] 20201914.
2010
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.
Nature genetics. 42(3):234-9 [DOI] 10.1038/ng.536. [PMID] 20154673.
2010
Does Ginkgo biloba reduce the risk of cardiovascular events?
Circulation. Cardiovascular quality and outcomes. 3(1):41-7 [DOI] 10.1161/CIRCOUTCOMES.109.871640. [PMID] 20123670.
2010
Is the urea cycle involved in Alzheimer’s disease?
Journal of Alzheimer's disease : JAD. 21(3):1013-21 [DOI] 10.3233/JAD-2010-100630. [PMID] 20693631.
2010
Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues.
Methods in molecular biology (Clifton, N.J.). 610:353-74 [DOI] 10.1007/978-1-60327-029-8_21. [PMID] 20013189.
2010
Revising the definition of Alzheimer’s disease: a new lexicon.
The Lancet. Neurology. 9(11):1118-27 [DOI] 10.1016/S1474-4422(10)70223-4. [PMID] 20934914.
2010
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer’s disease: a meta-analysis study.
Journal of Alzheimer's disease : JAD. 22(1):247-55 [DOI] 10.3233/JAD-2010-100933. [PMID] 20847397.
2010
Trajectories of cognitive decline in Alzheimer’s disease.
International psychogeriatrics. 22(2):281-90 [DOI] 10.1017/S1041610209991001. [PMID] 19781112.
2010
Traumatic brain injury–football, warfare, and long-term effects.
The New England journal of medicine. 363(14):1293-6 [DOI] 10.1056/NEJMp1007051. [PMID] 20879875.
2010
Traumatic brain injury: football, warfare, and long-term effects.
Minnesota medicine. 93(12):46-7 [PMID] 21265421.
2010
Trends in American Board of Psychiatry and Neurology specialties and neurologic subspecialties.
Neurology. 75(12):1110-7 [DOI] 10.1212/WNL.0b013e3181f39a41. [PMID] 20855855.
2010
Validation of consensus panel diagnosis in dementia.
Archives of neurology. 67(12):1506-12 [DOI] 10.1001/archneurol.2010.301. [PMID] 21149812.
2009
Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease.
The Journal of biological chemistry. 284(5):3158-3169 [DOI] 10.1074/jbc.M807731200. [PMID] 19059911.
2009
An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer’s disease hippocampus: relationship to neurofibrillary tangle progression.
Neuropathology : official journal of the Japanese Society of Neuropathology. 29(3):263-9 [DOI] 10.1111/j.1440-1789.2008.00978.x. [PMID] 19019179.
2009
Anti-Amyloid Effects of Small Molecule Aβ-Binding Agents in PS1/APP Mice.
Letters in drug design & discovery. 6(6) [PMID] 20119496.
2009
Association studies of 22 candidate SNPs with late-onset Alzheimer’s disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 150B(4):520-6 [DOI] 10.1002/ajmg.b.30851. [PMID] 18780302.
2009
Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(47):14770-8 [DOI] 10.1523/JNEUROSCI.3669-09.2009. [PMID] 19940172.
2009
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
Archives of neurology. 66(1):60-7 [DOI] 10.1001/archneurol.2008.511. [PMID] 19139300.
2009
Concomitant use of prescription drugs and dietary supplements in ambulatory elderly people.
Journal of the American Geriatrics Society. 57(7):1197-205 [DOI] 10.1111/j.1532-5415.2009.02329.x. [PMID] 19515113.
2009
Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 50(3):348-55 [DOI] 10.2967/jnumed.108.057612. [PMID] 19223409.
2009
Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease.
Archives of neurology. 66(5):646-51 [DOI] 10.1001/archneurol.2009.46. [PMID] 19433665.
2009
Evidence supporting a role for the calcium-sensing receptor in Alzheimer disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 150B(5):703-9 [DOI] 10.1002/ajmg.b.30896. [PMID] 19035514.
2009
Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer’s disease.
Proceedings of the National Academy of Sciences of the United States of America. 106(16):6820-5 [DOI] 10.1073/pnas.0900345106. [PMID] 19346482.
2009
Functional and cognitive criteria produce different rates of mild cognitive impairment and conversion to dementia.
Journal of neurology, neurosurgery, and psychiatry. 80(7):737-43 [DOI] 10.1136/jnnp.2008.160705. [PMID] 19279031.
2009
Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial.
JAMA. 302(24):2663-70 [DOI] 10.1001/jama.2009.1913. [PMID] 20040554.
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Identifying mild cognitive impairment at baseline in the Ginkgo Evaluation of Memory (GEM) study.
Aging & mental health. 13(2):171-82 [DOI] 10.1080/13607860802380656. [PMID] 19347684.
2009
Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease.
Journal of neurology, neurosurgery, and psychiatry. 80(6):600-7 [DOI] 10.1136/jnnp.2008.158964. [PMID] 19204022.
2009
Methodological issues in primary prevention trials for neurodegenerative dementia.
Journal of Alzheimer's disease : JAD. 16(2):235-70 [DOI] 10.3233/JAD-2009-0971. [PMID] 19221415.
2009
No association between CALHM1 variation and risk of Alzheimer disease.
Human mutation. 30(4):E566-9 [DOI] 10.1002/humu.20989. [PMID] 19191331.
2009
No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer’s disease.
Neurobiology of aging. 30(11):1890-1 [DOI] 10.1016/j.neurobiolaging.2008.01.006. [PMID] 18336955.
2009
Patterns of mild cognitive impairment after treatment of depression in the elderly.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 17(4):308-16 [DOI] 10.1097/JGP.0b013e318190b8d8. [PMID] 19307859.
2009
Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels.
Annals of neurology. 66(3):407-14 [DOI] 10.1002/ana.21731. [PMID] 19798641.
2009
The expanding role of genetics in the lewy body diseases: the glucocerebrosidase gene.
Archives of neurology. 66(5):555-6 [DOI] 10.1001/archneurol.2009.61. [PMID] 19433653.
2009
The relationship of excess cognitive impairment in MCI and early Alzheimer’s disease to the subsequent emergence of psychosis.
International psychogeriatrics. 21(1):78-85 [DOI] 10.1017/S1041610208007734. [PMID] 18814807.
2009
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer’s disease.
Molecular psychiatry. 14(11):1004-16 [DOI] 10.1038/mp.2009.10. [PMID] 19204726.
2008
Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer’s disease with Pittsburgh Compound B.
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2008
Clinical symptoms in Alzheimer’s disease.
Handbook of clinical neurology. 89:207-16 [DOI] 10.1016/S0072-9752(07)01219-5. [PMID] 18631745.
2008
Comparison of the design differences between the Ginkgo Evaluation of Memory study and the GuidAge study.
The journal of nutrition, health & aging. 12(1):73S-9S [PMID] 18165850.
2008
Frequency and correlates of advance planning among cognitively impaired older adults.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 16(8):643-9 [DOI] 10.1097/JGP.0b013e31816b7324. [PMID] 18669942.
2008
Frequent amyloid deposition without significant cognitive impairment among the elderly.
Archives of neurology. 65(11):1509-17 [DOI] 10.1001/archneur.65.11.1509. [PMID] 19001171.
2008
Ginkgo biloba for prevention of dementia: a randomized controlled trial.
JAMA. 300(19):2253-62 [DOI] 10.1001/jama.2008.683. [PMID] 19017911.
2008
Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B.
Alzheimer disease and associated disorders. 22(3):261-8 [DOI] 10.1097/WAD.0b013e31816c92bf. [PMID] 18580591.
2008
Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer’s disease.
NeuroImage. 39(2):619-33 [PMID] 17962045.
2008
Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer’s disease.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 56(12):1065-73 [DOI] 10.1369/jhc.2008.951855. [PMID] 18678882.
2008
Invited article: The ABPN maintenance of certification program for neurologists: past, present, and future.
Neurology. 71(8):599-604 [DOI] 10.1212/01.wnl.0000310815.29495.85. [PMID] 18596242.
2008
No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer’s disease.
Neurobiology of aging. 29(10):1602-4 [PMID] 17442457.
2008
No association of SORL1 SNPs with Alzheimer’s disease.
Neuroscience letters. 440(2):190-2 [DOI] 10.1016/j.neulet.2008.05.082. [PMID] 18562096.
2008
Oxidative lipidomics of programmed cell death.
Methods in enzymology. 442:375-93 [DOI] 10.1016/S0076-6879(08)01419-5. [PMID] 18662580.
2008
Pathways linking late-life depression to persistent cognitive impairment and dementia.
Dialogues in clinical neuroscience. 10(3):345-57 [PMID] 18979948.
2008
Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study.
Neurology. 70(19):1664-71 [DOI] 10.1212/01.wnl.0000306696.82017.66. [PMID] 18401021.
2008
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer’s disease.
Brain : a journal of neurology. 131(Pt 6):1630-45 [DOI] 10.1093/brain/awn016. [PMID] 18339640.
2008
Recollection and familiarity in amnestic mild cognitive impairment: a global decline in recognition memory.
Neuropsychologia. 46(7):1965-78 [DOI] 10.1016/j.neuropsychologia.2008.01.017. [PMID] 18328509.
2008
Taking the next steps in the diagnosis of Alzheimer’s disease: the use of biomarkers.
CNS spectrums. 13(3 Suppl 3):7-10 [PMID] 18564459.
2008
Turning over a new leaf: Ginkgo biloba in prevention of dementia?
Neurology. 70(19 Pt 2):1730-1 [DOI] 10.1212/01.wnl.0000311449.76944.6b. [PMID] 18458215.
2007
Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease.
Archives of neurology. 64(12):1771-6 [PMID] 18071042.
2007
Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(23):6174-84 [PMID] 17553989.
2007
Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans.
Archives of neurology. 64(4):541-4 [PMID] 17420316.
2007
Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer’s disease and associated quantitative traits.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 144B(1):79-82 [PMID] 16967469.
2007
Associations of gait speed and other measures of physical function with cognition in a healthy cohort of elderly persons.
The journals of gerontology. Series A, Biological sciences and medical sciences. 62(11):1244-51 [PMID] 18000144.
2007
Cholinergic forebrain degeneration in the APPswe/PS1DeltaE9 transgenic mouse.
Neurobiology of disease. 28(1):3-15 [PMID] 17662610.
2007
Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly.
Molecular psychiatry. 12(9):870-80 [PMID] 17579612.
2007
Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer’s disease.
Neurobiology of aging. 28(6):856-62 [PMID] 16725228.
2007
Imaging of amyloid burden and distribution in cerebral amyloid angiopathy.
Annals of neurology. 62(3):229-34 [PMID] 17683091.
2007
Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study.
Archives of neurology. 64(3):416-20 [PMID] 17353386.
2007
Marital quality in the context of mild cognitive impairment.
Western journal of nursing research. 29(8):976-92 [PMID] 17984481.
2007
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.
Archives of neurology. 64(3):431-4 [PMID] 17353389.
2007
Prediction of psychosis onset in Alzheimer disease: the role of depression symptom severity and the HTR2A T102C polymorphism.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 144B(8):1054-62 [PMID] 17525976.
2007
Redox-reactive autoantibodies in Alzheimer’s patients’ cerebrospinal fluids: preliminary studies.
Autoimmunity. 40(5):390-6 [PMID] 17612901.
2007
Redox-reactive autoantibodies in cerebrospinal fluids.
Annals of the New York Academy of Sciences. 1109:296-302 [PMID] 17785318.
2007
Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria.
The Lancet. Neurology. 6(8):734-46 [PMID] 17616482.
2007
Superior frontal cortex cholinergic axon density in mild cognitive impairment and early Alzheimer disease.
Archives of neurology. 64(9):1312-7 [PMID] 17846271.
2007
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.
Neurology. 68(18):1501-8 [PMID] 17470753.
2006
[11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease.
Neurology. 67(3):446-52 [PMID] 16894106.
2006
Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer’s disease.
Neurobiology of aging. 27(10):1435-9 [PMID] 16137793.
2006
Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria.
Biochimica et biophysica acta. 1757(5-6):648-59 [PMID] 16740248.
2006
Caregivers as subjects of clinical drug trials: a review of human subjects protection practices in published studies of Alzheimer’s disease pharmacotherapies.
IRB. 28(3):11-8 [PMID] 17036439.
2006
Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome.
Experimental neurology. 197(2):437-50 [PMID] 16300758.
2006
Chronic traumatic encephalopathy in a national football league player: part II.
Neurosurgery. 59(5):1086-92; discussion 1092 [PMID] 17143242.
2006
Cognitive correlates of cortical cholinergic denervation in Parkinson’s disease and parkinsonian dementia.
Journal of neurology. 253(2):242-7 [PMID] 16133720.
2006
Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer’s disease.
NeuroImage. 33(1):94-102 [PMID] 16905334.
2006
Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer’s disease.
Dementia and geriatric cognitive disorders. 21(4):205-14 [PMID] 16410678.
2006
Genetic association of ubiquilin with Alzheimer’s disease and related quantitative measures.
Molecular psychiatry. 11(3):273-9 [PMID] 16302009.
2006
Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer’s disease.
Neurobiology of aging. 27(10):1440-4 [PMID] 16223550.
2006
Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 26(7):915-26 [PMID] 16234845.
2006
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.
Annals of neurology. 59(3):512-9 [PMID] 16372280.
2006
Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer’s disease.
Neuroscience letters. 406(3):265-9 [PMID] 16914266.
2006
Lack of association of two chromosome 10q24 SNPs with Alzheimer’s disease.
Neuroscience letters. 408(3):170-2 [PMID] 17000046.
2006
Maintaining adherence and retention in dementia prevention trials.
Neurology. 67(9 Suppl 3):S14-6 [PMID] 17101928.
2006
Making sense of mild cognitive impairment: a qualitative exploration of the patient’s experience.
The Gerontologist. 46(6):791-800 [PMID] 17169934.
2006
Neuropsychological characteristics of mild cognitive impairment subgroups.
Journal of neurology, neurosurgery, and psychiatry. 77(2):159-65 [PMID] 16103044.
2006
Perspectives on assessing benefits and risks in clinical trials for Alzheimer’s disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association. 2(3):160-3 [DOI] 10.1016/j.jalz.2006.03.015. [PMID] 19595877.
2006
Prediction of psychosis onset in Alzheimer disease: The role of cognitive impairment, depressive symptoms, and further evidence for psychosis subtypes.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 14(4):352-60 [PMID] 16582044.
2006
Primary prevention trials in Alzheimer disease.
Neurology. 67(9 Suppl 3):S2-5 [PMID] 17101930.
2006
Recruitment of the elderly into a pharmacologic prevention trial: the Ginkgo Evaluation of Memory Study experience.
Contemporary clinical trials. 27(6):541-53 [PMID] 16949348.
2006
The “pro-apoptotic genies” get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes.
Chemico-biological interactions. 163(1-2):15-28 [PMID] 16797512.
2006
The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia.
Contemporary clinical trials. 27(3):238-53 [PMID] 16627007.
2006
The relation of white matter hyperintensities to cognitive performance in the normal old: education matters.
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. 13(3-4):326-40 [PMID] 16887777.
2006
Two-year follow-up of amyloid deposition in patients with Alzheimer’s disease.
Brain : a journal of neurology. 129(Pt 11):2805-7 [PMID] 17071918.
2006
Use of herbal medicine and other dietary supplements in community-dwelling older people: Baseline data from the ginkgo evaluation of memory study.
Journal of the American Geriatrics Society. 54(11):1725-35 [PMID] 17087700.
2006
X-34 labeling of abnormal protein aggregates during the progression of Alzheimer’s disease.
Methods in enzymology. 412:123-44 [PMID] 17046656.
2005
A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer’s type.
Current Alzheimer research. 2(5):541-51 [PMID] 16375657.
2005
Alteration of a clinically meaningful outcome in the natural history of Alzheimer’s disease by cholinesterase inhibition.
Journal of the American Geriatrics Society. 53(1):83-7 [PMID] 15667381.
2005
Alzheimer disease and mortality: a 15-year epidemiological study.
Archives of neurology. 62(5):779-84 [PMID] 15883266.
2005
Alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onset.
Biological psychiatry. 58(4):325-30 [PMID] 15978552.
2005
Apolipoprotein D is a component of compact but not diffuse amyloid-beta plaques in Alzheimer’s disease temporal cortex.
Neurobiology of disease. 20(2):574-82 [PMID] 15916898.
2005
Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer’s disease brain but not in transgenic mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(46):10598-606 [PMID] 16291932.
2005
Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment.
International journal of geriatric psychiatry. 20(6):512-22 [PMID] 15920711.
2005
Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.
Molecular psychiatry. 10(11):1026-36 [PMID] 16027741.
2005
Changes in hippocampal GABABR1 subunit expression in Alzheimer’s patients: association with Braak staging.
Acta neuropathologica. 109(5):467-74 [PMID] 15759131.
2005
Chronic traumatic encephalopathy in a National Football League player.
Neurosurgery. 57(1):128-34; discussion 128 [PMID] 15987548.
2005
Classification of vascular dementia in the Cardiovascular Health Study Cognition Study.
Neurology. 64(9):1539-47 [PMID] 15883314.
2005
Cognitive correlates of alterations in acetylcholinesterase in Alzheimer’s disease.
Neuroscience letters. 380(1-2):127-32 [PMID] 15854764.
2005
Cytochrome c, a biomarker of apoptosis, is increased in cerebrospinal fluid from infants with inflicted brain injury from child abuse.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 25(7):919-27 [PMID] 15744250.
2005
Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer’s disease.
Journal of neurology, neurosurgery, and psychiatry. 76(3):315-9 [PMID] 15716518.
2005
Dementia and Alzheimer’s disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort.
Journal of the American Geriatrics Society. 53(7):1101-7 [PMID] 16108925.
2005
Determinants of vascular dementia in the Cardiovascular Health Cognition Study.
Neurology. 64(9):1548-52 [PMID] 15883315.
2005
Development of a short form of the Severe Impairment Battery.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 13(11):999-1005 [PMID] 16286444.
2005
Differential cortical atrophy in subgroups of mild cognitive impairment.
Archives of neurology. 62(9):1393-7 [PMID] 16157746.
2005
Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease.
Neurology. 64(3):509-13 [PMID] 15699383.
2005
Heritability of psychosis in Alzheimer disease.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 13(7):624-7 [PMID] 16009739.
2005
Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies.
Archives of neurology. 62(2):196-200 [PMID] 15710847.
2005
Immunohistochemical study of the hnRNP A2 and B1 in the hippocampal formations of brains with Alzheimer’s disease.
Neuroscience letters. 386(2):111-5 [PMID] 15993539.
2005
Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer’s disease (AD) and quantitative measures of AD progression.
Neuroscience letters. 379(3):229-34 [PMID] 15843069.
2005
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 25(11):1528-47 [PMID] 15944649.
2005
Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer’s disease.
Archives of neurology. 62(3):425-30 [PMID] 15767507.
2005
Serum anticholinergic activity, white matter hyperintensities, and cognitive performance.
Neurology. 65(9):1487-9 [PMID] 16275844.
2005
Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment.
Archives of neurology. 62(6):953-7 [PMID] 15956166.
2005
Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 46(12):1959-72 [PMID] 16330558.
2005
Statin therapy in the treatment of Alzheimer disease: what is the rationale?
The American journal of medicine. 118 Suppl 12A:48-53 [PMID] 16356808.
2005
Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer’s disease.
Neurobiology of aging. 26(8):1161-5 [PMID] 15917099.
2004
Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtype.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 12(5):449-56 [PMID] 15353383.
2004
Alzheimer’s pathology in human temporal cortex surgically excised after severe brain injury.
Experimental neurology. 190(1):192-203 [PMID] 15473992.
2004
Detection and management of cognitive impairment in primary care: The Steel Valley Seniors Survey.
Journal of the American Geriatrics Society. 52(10):1668-75 [PMID] 15450043.
2004
Effects of donepezil on motor function in patients with Alzheimer disease.
Journal of clinical psychopharmacology. 24(3):354-6 [PMID] 15118497.
2004
Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies.
Journal of neurochemistry. 90(4):998-1004 [PMID] 15287906.
2004
Hemoglobin levels and Alzheimer disease: an epidemiologic study in India.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 12(5):523-6 [PMID] 15353391.
2004
Immunohistochemical study of hnRNP B1 in the postmortem temporal cortices of patients with Alzheimer’s disease.
Neuroscience research. 50(4):481-4 [PMID] 15567486.
2004
Mild cognitive impairment, amnestic type: an epidemiologic study.
Neurology. 63(1):115-21 [PMID] 15249620.
2004
Neuropathologic correlates of late-onset major depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 29(12):2242-50 [PMID] 15354182.
2004
NIFID: a new molecular pathology with a frontotemporal dementia phenotype.
Neurology. 63(8):1348-9 [PMID] 15505145.
2004
Right prosubiculum amyloid plaque density correlates with anosognosia in Alzheimer’s disease.
Journal of neurology, neurosurgery, and psychiatry. 75(10):1396-400 [PMID] 15377684.
2004
Time course analysis of hippocampal nerve growth factor and antioxidant enzyme activity following lateral controlled cortical impact brain injury in the rat.
Journal of neurotrauma. 21(5):491-500 [PMID] 15165358.
2003
22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion.
The Journal of biological chemistry. 278(15):13244-56 [PMID] 12547833.
2003
[Neuropathology of Alzheimer’s disease and mild cognitive impairment].
Revista de neurologia. 37(2):155-63 [PMID] 12938076.
2003
APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression.
International journal of geriatric psychiatry. 18(12):1075-81 [PMID] 14677138.
2003
Association of 3′-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer’s disease.
Journal of medical genetics. 40(6):424-30 [PMID] 12807963.
2003
Association of the 3′ UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer’s disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 117B(1):114-7 [PMID] 12555245.
2003
Blood pressure and cognitive impairment in India and the United States: a cross-national epidemiological study.
Archives of neurology. 60(8):1123-8 [PMID] 12925370.
2003
Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer’s neuropathology.
Journal of Alzheimer's disease : JAD. 5(1):39-48 [PMID] 12590165.
2003
Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study.
Archives of neurology. 60(12):1745-8 [PMID] 14676050.
2003
Early intervention is key to successful management of Alzheimer disease.
Alzheimer disease and associated disorders. 17 Suppl 4:S99-104 [PMID] 14512815.
2003
Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer’s disease patients with the A2M intronic deletion.
Neurobiology of disease. 14(3):504-12 [PMID] 14678766.
2003
Functional transitions and active life expectancy associated with Alzheimer disease.
Archives of neurology. 60(2):253-9 [PMID] 12580712.
2003
Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-Americans.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 116B(1):98-101 [PMID] 12497622.
2003
Hippocampal volume is associated with memory but not monmemory cognitive performance in patients with mild cognitive impairment.
Journal of molecular neuroscience : MN. 20(3):241-8 [PMID] 14501003.
2003
How should we design studies for stroke prevention?
Archives of neurology. 60(5):778-9 [PMID] 12756147.
2003
Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction.
Journal of chemical neuroanatomy. 26(4):233-42 [PMID] 14729126.
2003
Looking backward to move forward: early detection of neurodegenerative disorders.
Science (New York, N.Y.). 302(5646):830-4 [PMID] 14593169.
2003
Pathology and pathways of Alzheimer’s disease with an update on new developments in treatment.
Journal of the American Geriatrics Society. 51(5 Suppl Dementia):S314-20 [PMID] 12801388.
2003
Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer’s disease from 1983 to 2000.
The Journal of neuropsychiatry and clinical neurosciences. 15(1):67-73 [PMID] 12556574.
2003
Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer’s disease: correlation with cognitive impairment.
Annals of neurology. 53(1):81-90 [PMID] 12509851.
2003
Preservation of brain nerve growth factor in mild cognitive impairment and Alzheimer disease.
Archives of neurology. 60(8):1143-8 [PMID] 12925373.
2003
Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1.
Archives of neurology. 60(10):1385-9 [PMID] 14568808.
2003
Psychiatric symptoms vary with the severity of dementia in probable Alzheimer’s disease.
The Journal of neuropsychiatry and clinical neurosciences. 15(3):346-53 [PMID] 12928511.
2003
Psychotic symptoms in Alzheimer disease: evidence for subtypes.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 11(4):406-13 [PMID] 12837669.
2003
Relationship between apoE4 allele and excitatory amino acid levels after traumatic brain injury.
Critical care medicine. 31(9):2371-9 [PMID] 14501969.
2003
Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2.
Archives of neurology. 60(10):1394-9 [PMID] 14568809.
2003
Similar enzymes, different mechanisms: COX-1 and COX-2 enzymes in neurologic disease.
Archives of neurology. 60(4):632-3 [PMID] 12707083.
2003
The binding of 2-(4′-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(6):2086-92 [PMID] 12657667.
2003
Vascular cognitive impairment.
The Lancet. Neurology. 2(2):89-98 [PMID] 12849265.
2002
Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer’s disease.
Journal of geriatric psychiatry and neurology. 15(1):24-30 [PMID] 11936240.
2002
Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial.
Journal of molecular neuroscience : MN. 19(1-2):23-7 [PMID] 12212787.
2002
Changes in expression of amyloid precursor protein and interleukin-1beta after experimental traumatic brain injury in rats.
Journal of neurotrauma. 19(12):1555-67 [PMID] 12542857.
2002
Cholinesterase inhibitor treatment alters the natural history of Alzheimer’s disease.
Journal of neurology, neurosurgery, and psychiatry. 72(3):310-4 [PMID] 11861686.
2002
Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementia.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 10(3):321-7 [PMID] 11994220.
2002
Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer’s disease.
Human genetics. 110(4):356-65 [PMID] 11941486.
2002
Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer’s disease.
Neuroscience letters. 328(1):9-12 [PMID] 12123847.
2002
Increased familial risk of the psychotic phenotype of Alzheimer disease.
Neurology. 58(6):907-11 [PMID] 11914406.
2002
Linkage analysis of Alzheimer disease with psychosis.
Neurology. 59(1):118-20 [PMID] 12105318.
2002
Longitudinal increase in the volume of white matter hyperintensities in late-onset depression.
International journal of geriatric psychiatry. 17(6):526-30 [PMID] 12112176.
2002
Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology.
Neurobiology of aging. 23(4):547-53 [PMID] 12009504.
2002
Research evaluation and prospective diagnosis of dementia with Lewy bodies.
Archives of neurology. 59(1):43-6 [PMID] 11790229.
2002
The establishment of a brain bank for the study of late-life depression: a feasibility study of factors facilitating consent.
CNS spectrums. 7(11):816-21 [PMID] 12947244.
2002
The relation of White Matter Hyperintensities to implicit learning in healthy older adults.
International journal of geriatric psychiatry. 17(7):664-9 [PMID] 12112165.
2002
The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(14):6071-82 [PMID] 12122068.
2001
Alterations of striatal dopamine receptor binding in Alzheimer disease are associated with Lewy body pathology and antemortem psychosis.
Archives of neurology. 58(3):466-72 [PMID] 11255451.
2001
Epidemiology and pathophysiology of Alzheimer’s disease.
Clinical cornerstone. 3(4):15-26 [PMID] 11432119.
2001
Gender-specific aging effects on the serotonin 1A receptor.
Brain research. 895(1-2):9-17 [PMID] 11259754.
2001
Lack of association between alpha2-macroglobulin polymorphisms and Alzheimer’s disease.
Human genetics. 108(2):105-8 [PMID] 11281447.
2001
Patterns of cognitive decline in presymptomatic Alzheimer disease: a prospective community study.
Archives of general psychiatry. 58(9):853-8 [PMID] 11545668.
2001
Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology.
Neurology. 56(9):1143-53 [PMID] 11342678.
2001
Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology.
Neurology. 56(9):1133-42 [PMID] 11342677.
2001
Practice parameter: management of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology.
Neurology. 56(9):1154-66 [PMID] 11342679.
2001
The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease.
International psychogeriatrics. 13(4):401-9 [PMID] 12003247.
2001
The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease.
Archives of neurology. 58(9):1425-8 [PMID] 11559314.
2001
The Th1 versus Th2 cytokine profile in cerebrospinal fluid after severe traumatic brain injury in infants and children.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2(3):260-264 [PMID] 12793952.
2000
Analysis of genetic polymorphisms in the transforming growth factor-beta1 gene and the risk of Alzheimer’s disease.
Human genetics. 106(5):565-9 [PMID] 10914688.
2000
Apolipoprotein E polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study.
Archives of neurology. 57(6):824-30 [PMID] 10867779.
2000
Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented.
Neurology. 55(12):1847-53 [PMID] 11134384.
2000
Genetic association studies of interleukin-1 (IL-1A and IL-1B) and interleukin-1 receptor antagonist genes and the risk of Alzheimer’s disease.
Annals of neurology. 48(5):817-9 [PMID] 11079552.
2000
Genetic polymorphisms in the cathespin D and interleukin-6 genes and the risk of Alzheimer’s disease.
Neuroscience letters. 288(1):21-4 [PMID] 10869806.
2000
Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury.
Critical care medicine. 28(4):929-34 [PMID] 10809261.
2000
Predictors of progression in patients with AD and Lewy bodies.
Neurology. 54(9):1774-9 [PMID] 10802783.
2000
Promoting interactions with basic scientists and clinicians: the NIA Alzheimer’s Disease Data Coordinating Center.
Statistics in medicine. 19(11-12):1453-61 [PMID] 10844710.
2000
Psychotic symptoms in Alzheimer’s disease are not associated with more severe neuropathologic features.
International psychogeriatrics. 12(4):547-58 [PMID] 11263720.
2000
Research evaluation and diagnosis of possible Alzheimer’s disease over the last two decades: II.
Neurology. 55(12):1863-9 [PMID] 11134386.
2000
Research evaluation and diagnosis of probable Alzheimer’s disease over the last two decades: I.
Neurology. 55(12):1854-62 [PMID] 11134385.
2000
Severity of cognitive impairment and the clinical diagnosis of AD with Lewy bodies.
Neurology. 54(9):1780-7 [PMID] 10802784.
2000
Ten-year incidence of dementia in a rural elderly US community population: the MoVIES Project.
Neurology. 54(5):1109-16 [PMID] 10720283.
2000
Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory.
The Journal of neuropsychiatry and clinical neurosciences. 12(2):233-9 [PMID] 11001602.
1999
A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer’s disease.
Neuroscience letters. 263(2-3):129-32 [PMID] 10213152.
1999
Accuracy of four clinical diagnostic criteria for the diagnosis of neurodegenerative dementias.
Neurology. 53(6):1292-9 [PMID] 10522887.
1999
Differential effects of traumatic brain injury on vesicular acetylcholine transporter and M2 muscarinic receptor mRNA and protein in rat.
Journal of neurotrauma. 16(7):555-66 [PMID] 10447068.
1999
Genetic polymorphism in the persyn (gamma-synuclein) gene and the risk of Alzheimer’s disease.
Neuroscience letters. 261(3):186-8 [PMID] 10081980.
1999
Herpes simplex virus type 1 vector-mediated expression of nerve growth factor protects dorsal root ganglion neurons from peroxide toxicity.
Journal of virology. 73(1):519-32 [PMID] 9847358.
1999
Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice.
The Journal of clinical investigation. 104(5):647-56 [PMID] 10487779.
1999
Neutrophils do not mediate blood-brain barrier permeability early after controlled cortical impact in rats.
Journal of neurotrauma. 16(7):583-94 [PMID] 10447070.
1999
One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats.
Journal of neurotrauma. 16(2):109-22 [PMID] 10098956.
1999
PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders.
The American journal of psychiatry. 156(12):1871-8 [PMID] 10588399.
1999
Psychiatric medication and abnormal behavior as predictors of progression in probable Alzheimer disease.
Archives of neurology. 56(10):1266-72 [PMID] 10520944.
1999
Small head size is related to low Mini-Mental State Examination scores in a community sample of nondemented older adults.
Neurology. 53(1):228-9 [PMID] 10408569.
1999
The temporal relationship between depressive symptoms and dementia: a community-based prospective study.
Archives of general psychiatry. 56(3):261-6 [PMID] 10078504.
1998
Apolipoprotein E polymorphism in Alzheimer’s disease: a comparative study of two research populations from Spain and the United States.
European neurology. 39(4):229-33 [PMID] 9635474.
1998
Assessing the impact of neuropsychiatric symptoms in Alzheimer’s disease: the Neuropsychiatric Inventory Caregiver Distress Scale.
Journal of the American Geriatrics Society. 46(2):210-5 [PMID] 9475452.
1998
Association between ACT polymorphism and Alzheimer’s disease.
Neurology. 50(2):574-6 [PMID] 9508644.
1998
Astrocytes are the major source of nerve growth factor upregulation following traumatic brain injury in the rat.
Experimental neurology. 149(2):301-9 [PMID] 9500953.
1998
Augmented neuronal death in CA3 hippocampus following hyperventilation early after controlled cortical impact.
Journal of neurosurgery. 88(3):549-56 [PMID] 9488311.
1998
Bleomycin hydrolase is associated with risk of sporadic Alzheimer’s disease.
Nature genetics. 18(3):211-2 [PMID] 9500538.
1998
Chronic effects of traumatic brain injury on hippocampal vesicular acetylcholine transporter and M2 muscarinic receptor protein in rats.
Experimental neurology. 152(1):11-9 [PMID] 9682008.
1998
Dementia with Lewy bodies: response of delirium-like features to donepezil.
Neurology. 51(5) [PMID] 9818904.
1998
Dopamine receptor genetic variation, psychosis, and aggression in Alzheimer disease.
Archives of neurology. 55(10):1335-40 [PMID] 9779662.
1998
Epidermal growth factor receptor expression in skin does not predict dementia in the elderly.
Dementia and geriatric cognitive disorders. 9(1):20-3 [PMID] 9469260.
1998
Expression of differential immune factors in temporal cortex and cerebellum: the role of alpha-1-antichymotrypsin, apolipoprotein E, and reactive glia in the progression of Alzheimer’s disease.
The Journal of comparative neurology. 396(4):511-20 [PMID] 9651008.
1998
Genetic association of two chromosome 14 genes (presenilin 1 and alpha 1-antichymotrypsin) with Alzheimer’s disease.
Annals of neurology. 44(3):387-90 [PMID] 9749607.
1998
Genetic association studies between Alzheimer’s disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.
Neuroscience letters. 244(2):65-8 [PMID] 9572586.
1998
Neurologic factors associated with cognitive impairment in a rural elderly population in India: the Indo-US Cross-National Dementia Epidemiology Study.
Journal of geriatric psychiatry and neurology. 11(1):11-7 [PMID] 9686747.
1998
Practical issues in cognitive screening of elderly illiterate populations in developing countries. The Indo-US Cross-National Dementia Epidemiology Study.
Aging (Milan, Italy). 10(5):349-57 [PMID] 9932138.
1998
Prevalence of Alzheimer’s disease and other dementias in rural India: the Indo-US study.
Neurology. 51(4):1000-8 [PMID] 9781520.
1998
Quinolinic acid is increased in CSF and associated with mortality after traumatic brain injury in humans.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 18(6):610-5 [PMID] 9626184.
1998
Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction.
Brain research. 813(1):167-71 [PMID] 9824691.
1998
Serotonin in aging, late-life depression, and Alzheimer’s disease: the emerging role of functional imaging.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 18(6):407-30 [PMID] 9571651.
1998
Soluble adhesion molecules in CSF are increased in children with severe head injury.
Journal of neurotrauma. 15(10):777-87 [PMID] 9814634.
1998
Up-regulation of type 2 iodothyronine deiodinase mRNA in reactive astrocytes following traumatic brain injury in the rat.
Journal of neurochemistry. 71(2):887-90 [PMID] 9681483.
1997
Assessment of cerebral blood flow and CO2 reactivity after controlled cortical impact by perfusion magnetic resonance imaging using arterial spin-labeling in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 17(8):865-74 [PMID] 9290584.
1997
Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock.
Acta neurochirurgica. Supplement. 70:96-7 [PMID] 9416290.
1997
Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer’s Association, and the American Geriatrics Society.
JAMA. 278(16):1363-71 [PMID] 9343469.
1997
Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact injury in rats.
Journal of neurotrauma. 14(4):179-89 [PMID] 9151767.
1997
EEG spectral abnormalities and psychosis as predictors of cognitive and functional decline in probable Alzheimer’s disease.
Neurology. 48(6):1521-5 [PMID] 9191759.
1997
Expression of fetal ALZ-50 reactive clone 1 (FAC1) in dentate gyrus following entorhinal cortex lesion.
The Journal of comparative neurology. 386(4):555-61 [PMID] 9378851.
1997
Extrapyramidal signs in patients with probable Alzheimer disease.
Archives of neurology. 54(8):969-75 [PMID] 9267971.
1997
Fetal grafting for Parkinson’s disease: expression of immune markers in two patients with functional fetal nigral implants.
Cell transplantation. 6(3):213-9 [PMID] 9171154.
1997
Gender-specific nonrandom association between the alpha 1-antichymotrypsin and apolipoprotein E polymorphisms in the general population and its implication for the risk of Alzheimer’s disease.
Genetic epidemiology. 14(2):169-80 [PMID] 9129962.
1997
Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children.
Journal of neurotrauma. 14(7):451-7 [PMID] 9257663.
1997
Perfusion MRI assessment of cerebral blood flow and CO2 reactivity after controlled cortical impact in rats.
Advances in experimental medicine and biology. 411:7-12 [PMID] 9269406.
1997
Psychiatric correlates of MR deep white matter lesions in probable Alzheimer’s disease.
The Journal of neuropsychiatry and clinical neurosciences. 9(2):246-50 [PMID] 9144104.
1997
Re: Genetic effect of alpha 1-antichymotrypsin on the risk of Alzheimer disease.
Genomics. 40(2):382-5 [PMID] 9119413.
1997
The antioxidant enzymes glutathione peroxidase and catalase increase following traumatic brain injury in the rat.
Experimental neurology. 146(1):291-4 [PMID] 9225764.
1997
The apolipoprotein E epsilon 4 allele is not associated with psychiatric symptoms or extrapyramidal signs in probable Alzheimer’s disease.
Neurology. 49(3):794-7 [PMID] 9305342.
1997
The effect of brain temperature on acute inflammation after traumatic brain injury in rats.
Journal of neurotrauma. 14(8):561-72 [PMID] 9300566.
1997
Treatment of traumatic brain injury with moderate hypothermia.
The New England journal of medicine. 336(8):540-6 [PMID] 9023090.
1996
Alterations in functional neuroanatomical connectivity in Alzheimer’s disease. Positron emission tomography of auditory verbal short-term memory.
Annals of the New York Academy of Sciences. 777:239-42 [PMID] 8624091.
1996
Antibodies against Mac-1 attenuate neutrophil accumulation after traumatic brain injury in rats.
Journal of neurotrauma. 13(6):333-41 [PMID] 8835801.
1996
Association between dementia and elevated TSH: a community-based study.
Biological psychiatry. 40(8):714-25 [PMID] 8894063.
1996
Cognitive stability over 2 years in a rural elderly population: the MoVIES project.
Neuroepidemiology. 15(1):42-50 [PMID] 8719048.
1996
Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer’s disease.
Neurology. 46(3):692-700 [PMID] 8618669.
1996
Dementia associated with dorsal midbrain lesion.
Journal of the International Neuropsychological Society : JINS. 2(4):359-67 [PMID] 9375185.
1996
Effect of education and gender adjustment on the sensitivity and specificity of a cognitive screening battery for dementia: results from the MoVIES Project. Monongahela Valley Independent Elders Survey.
Neuroepidemiology. 15(6):321-9 [PMID] 8930945.
1996
Functional connectivity in auditory-verbal short-term memory in Alzheimer’s disease.
NeuroImage. 4(2):67-77 [PMID] 9345498.
1996
Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain.
Annals of neurology. 39(1):123-7 [PMID] 8572657.
1996
Mild posttraumatic hypothermia reduces mortality after severe controlled cortical impact in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 16(2):253-61 [PMID] 8594057.
1996
Polygenic determinants of Alzheimer’s disease: modulation of the risk by alpha-1-antichymotrypsin.
Annals of the New York Academy of Sciences. 802:27-34 [PMID] 8993481.
1996
Resuscitation from severe brain trauma.
Critical care medicine. 24(2 Suppl):S48-56 [PMID] 8608706.
1996
Structural correlates of cognition in dementia: quantification and assessment of synapse change.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 5(4):417-21 [PMID] 9117556.
1995
Alternate strategies in lesion-induced reactive synaptogenesis: differential expression of L1 in two populations of sprouting axons.
Experimental neurology. 131(2):165-73 [PMID] 7895817.
1995
APOE*4-associated Alzheimer’s disease risk is modified by alpha 1-antichymotrypsin polymorphism.
Nature genetics. 10(4):486-8 [PMID] 7670501.
1995
Apolipoprotein E genotyping in the diagnosis of Alzheimer’s disease.
Annals of neurology. 38(6):967-70 [PMID] 8526476.
1995
Computed tomography–but not magnetic resonance imaging–identified periventricular white-matter lesions predict symptomatic cerebrovascular disease in probable Alzheimer’s disease.
Archives of neurology. 52(7):659-64 [PMID] 7619020.
1995
Dementia among elderly apolipoprotein E type 4/4 homozygotes: a prospective study.
Genetic epidemiology. 12(3):309-11 [PMID] 7557352.
1995
Electroencephalographic correlates of periventricular white matter lesions in probable Alzheimer’s disease.
Dementia (Basel, Switzerland). 6(6):343-7 [PMID] 8563788.
1995
Hypothermia attenuates the normal increase in interleukin 1 beta RNA and nerve growth factor following traumatic brain injury in the rat.
Journal of neurotrauma. 12(2):159-67 [PMID] 7629862.
1995
Symptoms of depression in Alzheimer’s disease, frontal lobe-type dementia, and subcortical dementia.
Annals of the New York Academy of Sciences. 769:389-92 [PMID] 8595040.
1994
Awareness of cognitive deficits and anosognosia in probable Alzheimer’s disease.
European neurology. 34(5):277-82 [PMID] 7995303.
1994
Dementia accompanying motor neuron disease.
Dementia (Basel, Switzerland). 5(1):42-7 [PMID] 8156086.
1994
Embryonic neural cell adhesion molecule (N-CAM) is elevated in the denervated rat dentate gyrus.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 14(7):4217-25 [PMID] 8027773.
1994
Functional neuroanatomy of verbal free recall: A replication study.
Human brain mapping. 1(4):284-92 [DOI] 10.1002/hbm.460010406. [PMID] 24591197.
1994
Increased transmitter amino acid concentration in human ventricular CSF after brain trauma.
Neuroreport. 6(1):153-6 [PMID] 7703404.
1994
Rapid expression and transport of embryonic N-CAM in dentate gyrus following entorhinal cortex lesion: ultrastructural analysis.
The Journal of comparative neurology. 349(3):486-92 [PMID] 7852638.
1994
Reliability of NINDS-AIREN clinical criteria for the diagnosis of vascular dementia.
Neurology. 44(7):1240-5 [PMID] 8035923.
1994
Upregulation of nerve growth factor following cortical trauma.
Experimental neurology. 130(2):173-7 [PMID] 7867748.
1993
Effects of a history of heavy alcohol consumption on Alzheimer’s disease.
The British journal of psychiatry : the journal of mental science. 163:358-63 [PMID] 8401966.
1993
Epidermal growth factor receptor expression in demented elderly: localization to vascular endothelial cells of brain, pituitary and skin.
Brain research. 615(2):181-90 [PMID] 7689911.
1993
Monoamine neurons in aging and Alzheimer’s disease.
Journal of neural transmission. General section. 91(2-3):135-59 [PMID] 8099796.
1993
Regional distribution of neural cell adhesion molecule (N-CAM) and L1 in human and rodent hippocampus.
The Journal of comparative neurology. 327(3):341-9 [PMID] 7680048.
1993
Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model.
Journal of neurochemistry. 61(6):2015-24 [PMID] 7504079.
1992
Amygdala cell loss and atrophy in Alzheimer’s disease.
Annals of neurology. 32(4):555-63 [PMID] 1456740.
1992
Cortical biopsy in Alzheimer’s disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group.
Annals of neurology. 32(5):625-32 [PMID] 1360195.
1992
Monoaminergic and cholinergic synaptic markers in the nucleus basalis of Meynert (nbM): normal age-related changes and the effect of heart disease and Alzheimer’s disease.
Annals of neurology. 31(6):611-20 [PMID] 1355334.
1992
Neurotrophic effects of steroids on lesion-induced growth in the hippocampus. II. Hormone replacement.
Experimental neurology. 118(1):47-52 [PMID] 1397175.
1991
Quantitation of synaptic density in the septal nuclei of young and aged Fischer 344 rats.
Neurobiology of aging. 12(1):3-12 [PMID] 2002880.
1991
Volumetric atrophy of the amygdala in Alzheimer’s disease: quantitative serial reconstruction.
Neurology. 41(3):351-6 [PMID] 2006000.
1990
Assessing utility of single photon emission computed tomography (SPECT) scan in Alzheimer disease: correlation with cognitive severity.
Alzheimer disease and associated disorders. 4(1):14-23 [PMID] 2317335.
1990
I-123 hydroxyiodobenzyl propanediamine (HIPDM) cerebral blood flow imaging demonstrating transtentorial diaschisis.
Clinical nuclear medicine. 15(9):623-9 [PMID] 2208883.
1990
Quantitative assessment of cortical synaptic density in Alzheimer’s disease.
Neurobiology of aging. 11(1):29-37 [PMID] 2325814.
1990
Synapse loss in frontal cortex biopsies in Alzheimer’s disease: correlation with cognitive severity.
Annals of neurology. 27(5):457-64 [PMID] 2360787.
1989
Acetylcholine synthesis in human CSF: implications for study of central cholinergic metabolism.
Neurochemical research. 14(2):191-6 [PMID] 2725819.
1989
Cognitive mental status examinations.
Clinics in geriatric medicine. 5(3):545-64 [PMID] 2680033.
1989
Glucocorticoid suppression of lesion-induced synaptogenesis: effect of temporal manipulation of steroid treatment.
Experimental neurology. 105(3):260-4 [PMID] 2767199.
1988
Alzheimer’s disease. Aminergic-cholinergic alterations in hypothalamus.
Archives of neurology. 45(9):994-9 [PMID] 2901257.
1988
Hydrocortisone differentially alters lesion-induced axon sprouting in male and female rats.
Experimental neurology. 100(1):237-41 [PMID] 3350092.
1988
Neurotrophic effects of steroids on lesion-induced growth in the hippocampus. I. The asteroidal condition.
Brain research. 457(2):246-50 [PMID] 3219553.
1987
Altered striatal dopaminergic metabolism 36 hours after unilateral trauma to the human mesencephalon.
Neurology. 37(2):322-5 [PMID] 3808316.
1987
Iodine-123 HIPDM brain imaging findings in subacute spongiform encephalopathy (Creutzfeldt-Jakob disease).
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 28(9):1484-7 [PMID] 3305807.
1986
Gonadal steroids influence axon sprouting in the hippocampal dentate gyrus: a sexually dimorphic response.
Experimental neurology. 94(3):649-58 [PMID] 3780911.
1986
Perinatal glucocorticoids disrupt learning: a sexually dimorphic response.
Physiology & behavior. 36(1):145-9 [PMID] 3952174.
1986
Reactive synaptogenesis in hippocampal area CA1 of aged and young adult rats.
The Journal of comparative neurology. 252(3):374-84 [PMID] 3793982.
1986
Stability of sialogangliosides in kindled hippocampus.
Experimental neurology. 91(1):208-11 [PMID] 2866974.
1985
Laminar organization of cholinergic circuits in human frontal cortex in Alzheimer’s disease and aging.
Neurology. 35(10):1425-31 [PMID] 4033925.
1985
Perinatal glucocorticoids alter dentate gyrus electrophysiology.
Brain research bulletin. 15(2):111-6 [PMID] 2994854.
1985
Strain comparison of synaptic density in hippocampal CA1 of aged rats.
Neurobiology of aging. 6(1):29-34 [PMID] 4000383.
1985
Strain differences and laminar localization of structural neurochemical changes in aging rat.
Neurobiology of aging. 6(4):277-86 [PMID] 4088423.
1984
Elevated corticosterone levels. A possible cause of reduced axon sprouting in aged animals.
Neuroendocrinology. 38(1):33-8 [PMID] 6537997.
1983
Steroid suppression of axon sprouting in the hippocampal dentate gyrus of the adult rat: dose-response relationship.
Experimental neurology. 82(1):183-91 [PMID] 6628607.
1982
Aging, senile dementia, and the intralaminar microchemistry of cerebral cortex.
Neurology. 32(11):1227-33 [PMID] 6182504.
1982
Morphologic and behavioral effects of perinatal glucocorticoid administration.
Physiology & behavior. 29(5):895-900 [PMID] 7156227.
1980
Recognition and discrimination of emotional faces and pictures.
Brain and language. 9(2):206-14 [PMID] 7363065.

Grants

May 2023 ACTIVE
Using Artificial Intelligence to Predict Cognitive Training Response in Amnestic Mild Cognitive Impairment
Role: Other
Funding: NATL INST OF HLTH NIA
Feb 2023 ACTIVE
Eligibility criteria design for Alzheimers trials with real-world data and explainable AI
Role: Co-Investigator
Funding: WEILL MED COLLEGE OF CORNELL UNIV via NATL INST OF HLTH NIA
Sep 2022 ACTIVE
ACTIVE MIND: An adaptive clinical trial of cognitive training to improve function and delay dementia
Role: Co-Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIA
Sep 2022 ACTIVE
Opioid Prescribing Practices and Health Outcomes among Patients with Alzheimers Disease and Related Dementia
Role: Co-Investigator
Funding: OHIO STATE UNIV via NATL INST OF HLTH NIA
Mar 2022 ACTIVE
Computational Drug Repurposing for AD/ADRD with Integrative Analysis of Real-World Data and Biomedical Knowledge
Role: Co-Investigator
Funding: WEILL MED COLLEGE OF CORNELL UNIV via NATL INST OF HLTH NIA
Apr 2021 ACTIVE
Advancing Drug Repositioning for Alzheimers Disease using Real-world Data
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Feb 2021 ACTIVE
Cognitive Training to Reduce Incidence of Cognitive Impairment in Older Adults
Role: Co-Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIA
Jan 2021 ACTIVE
Behavioral and neural properties of spatial direction comprehension in aging and amestic mild cognitive impairment
Role: Other
Funding: NATL INST OF HLTH NIA
Jun 2020 ACTIVE
1Florida Alzheimers Disease Research Center
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Aug 2019 ACTIVE
Revitalizing Cognition in Older Adults at Risk for Alzheimer's Disease with Near-Infrared Photobiomodulation.
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
May 2019 – Aug 2021
Association of PET amyloid status with cognitive and functional outcomes of behavioral interventions in Mild Cognitive Impairment
Role: Co-Investigator
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Sep 2018 – May 2022
Planning an Adaptive Clinical Trial of Cognitive Training to Improve Function and Delay Dementia
Role: Co-Investigator
Funding: UNIV OF SOUTH FLORIDA via NATL INST OF HLTH NIA
Feb 2018 – Feb 2020
The Relationships between Multimodal Neuroimaging Biomarkers and Novel Cognitive Stress Tests Among Ethnically Divers
Role: Principal Investigator
Funding: UNIV OF MIAMI via FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Sep 2017 – May 2022
Treatment of mild cognitive impairment with transcutaneous vagal nerve stimulation
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Sep 2016 – Apr 2023
Augmenting Cognitive Training in Older Adults – The ACT Grant
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Aug 2015 – May 2021
University of Florida – Mt. Sinai Medical Center AD Research Center
Role: Co-Project Director/Principal Investigator
Funding: NATL INST OF HLTH NIA
Mar 2015 – Apr 2020
Texas External Quality Review Organization Vendor and Quality Vendor
Role: Project Manager
Funding: STATE OF TEXAS HLTH HUMAN SERV COM via CTRS FOR MEDICARE & MEDICAID SERVICES
Nov 2012 – Oct 2017
Support brain research at the McKnight Brain Institute
Role: Principal Investigator
Funding: UF FOUNDATION
Nov 2012 – Oct 2017
Support Stem Cell Research , also knows as regeneration medicine, associated with the the McKnight Brain Institute
Role: Project Manager
Funding: UF FOUNDATION
Sep 2012 – Sep 2016
IPA – Song Lai
Role: Project Manager
Funding: US DEPT OF VETERANS AFFAIRS
Jul 2012 – Jan 2018
Support the operations and functions of the McKnight Brain Bank at the McKnight Brain Institute.
Role: Principal Investigator
Funding: UF FOUNDATION
Apr 2008 ACTIVE
Evelyn F. McKnight Brain Research Program in Age-Related Memory Loss.
Role: Principal Investigator
Funding: MCKNIGHT FOU
Apr 2008 – Apr 2018
McKnight Brain Research Program
Role: Project Manager
Funding: UF FOUNDATION
Jul 2006 ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
Role: Principal Investigator
Funding: FL DEPT OF HLTH

Education

Fellow in Neurochemistry
1978-1979 · University of Virginia School of Medicine
Resident in Neurology
1975-1978 · University of Florida College of Medicine
Intern in Internal Medicine
1974-1975 · The Johns Hopkins Hospital, Baltimore, MD
MD
1971-1974 · University of Florida College of Medicine
Graduate Student, Psychology and Neuroscience
1968-1971 · University of Florida College of Medicine
B.A. in Psychology
1964-1968 · Bucknell University, Lewisburg, PA

Contact Details

Phones:
Business:
(352) 273-8500
Addresses:
Business Mailing:
PO Box 100236
GAINESVILLE FL 32610
Business Street:
1149 SOUTH NEWELL DRIVE
MCKNIGHT BRAIN INSTITUTE
GAINESVILLE FL 326103260